excitatory synapse

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excitatory synapse

A synapse which, on activation, increases the likelihood of an action potential on the post-synaptic neuron or increases the frequency of firing of the post-synaptic neuron.


the junction between the processes of two neurons or between a neuron and an effector organ, where neural impulses are transmitted by chemical means. The impulse causes the release of a neurotransmitter (e.g. acetylcholine or norepinephrine) from the presynaptic membrane of the axon terminal. The neurotransmitter molecules diffuse across the synaptic cleft, bind with specific receptors on the postsynaptic membrane, causing depolarization or hyperpolarization of the postsynaptic cell. See also neuron.

adrenergic synapse
the neurotransmitter is norepinephrine. See also adrenergic (1).
axoaxonic synapse
axodendritic synapse
axodendrosomatic synapse
one between the axon of one neuron and the dendrites and body of another.
axosomatic synapse
cholinergic synapse
the neurotransmitter is acetylcholine. See also cholinergic.
dendrodendritic synapse
one from a dendrite of one cell to a dendrite of another.
excitatory synapse
a synapse in which the transmission of impulses is electrical not chemical. Found only in fish and invertebrates.
inhibitory synapse
hyperpolarizing electrical current is used to raise the threshold for the stimulation of a discharge of an impulse from the particular kind of nerve cell, found only in fish.
References in periodicals archive ?
Specifically, in the ventral tegmental area (VTA) of the brain, endocannibinoids play a significant role in weakening the excitatory synapses onto dopamine neurons.
Although dendritic spines are taken as a structural marker of excitatory synapses, a subset of neurons, such as forebrain inhibitory neurons, develop dendrites with few spines and receive most of the excitatory synapses directly onto dendritic shafts.
org/content/355/6324/511) a summary of their findings in the journal under the title "Homer1a drives homeostatic scaling-down of excitatory synapses during sleep.
The role of synaptic plasticity at excitatory synapses is established for such adaptations.
When enough excitatory synapses are activated simultaneously, the neuron conducts a regenerative electrical wave of depolarization along its axon.
Because the excitatory synapses that we are studying form their connections right after birth in humans, we think these specific pathways may even provide an opportunity for early intervention after birth," Soderling said.
The excitatory synapses show both synaptic active sites and postsynaptic densities, as can be observed in Fig.
Presynaptic protein complexin I is a marker of inhibitory synapses, and complexin II is a marker of excitatory synapses.
Lewis believes that these changes occur because axon terminals containing excitatory synapses are eliminated during puberty.
This condition results when, as a result of injury, there is abnormal activity at excitatory synapses, which essentially stimulate the nerve cells to death.
The results we obtain will be useful to rationally interfere with excitatory synapses in the brain and may therefore help the development of therapies.