excision repair

(redirected from Excision repair mechanism)

ex·ci·sion re·pair

the use of a complementary DNA strand as a template to replace a damaged segment of DNA.

excision repair

Correction of DNA damage by the removal of the damaged length of single strand by one of a number of enzymes capable of recognizing damaged nucleotides, and resynthesizing the correct nucleotide sequence complementary to the normal strand. The repair is catalyzed by DNA polymerase I and DNA ligase.

excision repair

the removal of damaged polynucleotide segments from DNA (e.g. THYMINE DIMERS produced by ultraviolet light) and replacement with a correct segment using DNA POLYMERASE and DNA LIGASE.
References in periodicals archive ?
PARP inhibitors may block base excision repair mechanisms, trap PARP enzymes on damaged DNA, reduce the affinity of functioning BRCA enzymes to damaged DNA, and suppress nonhomologous end joining repair mechanisms.