excision repair


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ex·ci·sion re·pair

the use of a complementary DNA strand as a template to replace a damaged segment of DNA.

excision repair

Correction of DNA damage by the removal of the damaged length of single strand by one of a number of enzymes capable of recognizing damaged nucleotides, and resynthesizing the correct nucleotide sequence complementary to the normal strand. The repair is catalyzed by DNA polymerase I and DNA ligase.

excision repair

the removal of damaged polynucleotide segments from DNA (e.g. THYMINE DIMERS produced by ultraviolet light) and replacement with a correct segment using DNA POLYMERASE and DNA LIGASE.
References in periodicals archive ?
It has been proposed that the SUV[sub]max of tumors may correlate with the presence or absence of chemotherapy resistance-associated biomarkers based on studies that have displayed a close correlation between SUV[sub]max and the expression levels of excision repair cross-complementary Group 1 (ERCC1)[sup][1] and Tp53-induced glycolysis and apoptosis regulator.
What's more, this technique is not limited to reading damage caused by BPDE, but can be used for any type of DNA damage that uses something called nucleotide excision repair.
Known as nucleotide excision repair, it involves the recruitment of special proteins that perform DNA surgery.
PARP inhibitors may block base excision repair mechanisms, trap PARP enzymes on damaged DNA, reduce the affinity of functioning BRCA enzymes to damaged DNA, and suppress nonhomologous end joining repair mechanisms.
1] Such DNA damage can be corrected by some DNA repair mechanisms such as base excision repair (BER), nucleotide excision repair (NER), double strand break repair (DSBR) and, DNA mismatch repair (DMR) which play a crucial role in maintenance of genomic integrity.
4) These DNA lesions can be repaired by the nucleotide excision repair pathway.
Breaks limited to single strands of DNA are fixed by processes known as base excision repair (BER), nucleotide excision repair (NER), and mismatch repair (MMR).
Stalled RNAPII triggers transcription-coupled nucleotide excision repair, a process whereby lesions in genes are preferentially removed.
The Ku70-deficient cell line is sensitive to oxidizing agents, and its deficiency in double-strand break repair by nonhomologous end joining, which also serves as a back-up repair pathway for the base excision repair (BER) pathway, provides a window into the cellular responses to oxidatively induced DNA damage (Choi et al.
The company stated TRC102 (methoxyamine) is a novel, clinical-stage small molecule inhibitor of the DNA base excision repair pathway, which is a pathway that causes resistance to alkylating and antimetabolite chemotherapeutics.
There are three DNA repair systems namely: mismatch repair, nucleotide excision repair and recombination repair.