alkylglycerol

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alkylglycerol

Fringe oncology
A compound esterified with a fatty acid. The most abundant source of alkylglycerols is shark liver oil; it also can be found in red blood cells (erythrocytes), bone marrow, liver, spleen and breast milk. Alkylglycerols, in particular butyl alcohol, stimulate haematopoiesis and the immune system.

While shark liver oil has been heavily promoted as a dietary supplement for preventing or for managing leukaemias and other malignancies, there is no supporting scientific evidence.
References in periodicals archive ?
FAROOQUI is a leader in the fields of signal transduction, brain phospholipase A2, bioactive ether lipid metabolism, and polyunsaturated fatty acid metabolism, among others.
ELL-12, a novel ether lipid which we expect to enter into Phase II trials for renal cell carcinoma, metastatic melanoma, non-small cell lung cancer and myelodysplastic syndrome.
TLC ELL-12 is a liposomal ether lipid, developed from the Company's research efforts into bioactive lipids.
Liposome Company scientists have developed a liposomal formulation, which reduces these toxicities yet retains, and in some cases enhances, the tumor- specific killing properties seen in the free ether lipid.
The Company's product pipeline includes TLC ELL-12 , liposomal ether lipid, which is in development to treat various cancers.
The R&D spending was primarily related to clinical development activities relating to the Phase III study of EVACET(TM) (formerly TLC D-99), a treatment for metastatic breast cancer, for which the Company expects to file a New Drug Application (NDA) in the latter portion of this year, as well as preclinical toxicology studies of TLC ELL-12, liposomal ether lipid, which can be used to treat various cancers.
One presentation describes research in the development of liposomal ether lipid, and the other compares the efficacy of bromotaxol versus paclitaxel (a chemotherapeutic sold under the brand name Taxol(R), a trademark of the Bristol-Myers Squibb Company) in murine models.
The Company has recently commenced preclinical toxicology studies on a novel ether lipid formulation, Mr.
They possess a unique cell envelope with a cytoplasmic membrane of ether lipids surrounded by a proteinaceous S-layer and various cell appendages such as flagella, pili and more unusual structures.
Sorting out their individual functions has been difficult and in some cases controversial as they share structural domains and generally have been tested outside the context of key components such as the major glycolipid lipohosphoglycan (LPG) and phosphoglycans (PGs); ether lipids, which constitute approximately 20% of the membrane lipids and most GPI anchors; and others.