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estrogen receptor |
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estrogen receptor A protein of a superfamily of nuclear receptors for small hydrophilic ligands–eg, steroid hormones, thyroid hormone, vitamin D, retinoids; the presence of ERs in breast CA generally is associated with a better
prognosis, as they respond to hormonal manipulation. See Tamoxifen. ERs are transcription factors that are regulated allosterically by binding a ligand; extracellular estradiol diffuses across the cell membrane, binds to the ER, leading to its
dimerization and binding of ER to the estrogen responsive element, the ER's specific DNA target How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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The role of selective estrogen receptor modulators in the prevention of breast cancer: comparison of the clinical trials. In publishing this section in Southern Medical Journal, the Southern Medical Association recognizes educational needs of physicians in all specialties, especially those in primary care, for current information regarding selective estrogen receptor modulators. raloxifene), part of a new class of drugs called SERMS, or selective estrogen receptor modulators, compounds that provide estrogen's bone-protecting benefits without many of its cancer-causing risks, and Actonel (risedronate) another drug in the same class as Fosamax, called bisphosphonates. |
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