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estrogen receptor |
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estrogen receptor A protein of a superfamily of nuclear receptors for small hydrophilic ligands–eg, steroid hormones, thyroid hormone, vitamin D, retinoids; the presence of ERs in breast CA generally is associated with a better
prognosis, as they respond to hormonal manipulation. See Tamoxifen. ERs are transcription factors that are regulated allosterically by binding a ligand; extracellular estradiol diffuses across the cell membrane, binds to the ER, leading to its
dimerization and binding of ER to the estrogen responsive element, the ER's specific DNA target How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Expression of estrogen receptor beta in the fetal, neonatal, and prepubertal human prostate. GTx is also developing two other product candidates, GTx-838, another GTx SARM, for the treatment of sarcopenia, and GTx-878, an estrogen receptor beta agonist for the treatment of benign prostatic hyperplasia and chronic prostatitis. Differential response of estrogen receptor alpha and estrogen receptor beta to partial estrogen agonists/antagonists. |
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