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estrogen receptor |
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estrogen receptor A protein of a superfamily of nuclear receptors for small hydrophilic ligands–eg, steroid hormones, thyroid hormone, vitamin D, retinoids; the presence of ERs in breast CA generally is associated with a better
prognosis, as they respond to hormonal manipulation. See Tamoxifen. ERs are transcription factors that are regulated allosterically by binding a ligand; extracellular estradiol diffuses across the cell membrane, binds to the ER, leading to its
dimerization and binding of ER to the estrogen responsive element, the ER's specific DNA target How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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| ? Mentioned in | ? References in periodicals archive | |
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Differential response of estrogen receptor alpha and estrogen receptor beta to partial estrogen agonists/antagonists. A second experiment revealed a profusion of estrogen receptor alpha on the surface of tumor cells, she says. Nongenomic actions of estrogens and xenoestregens by binding at a plasma membrane receptor unrelated to estrogen receptor alpha and estrogen receptor beta. |
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