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estramustine

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estramustine /es·tra·mus·tine/ (-mus´tēn) an antineoplastic containing estradiol joined to mechlorethamine, used for palliative treatment of metastatic or progressive carcinoma of the prostate; used as e. phosphate sodium.
estramustine
[es′trämus′tēn]
an antineoplastic agent containing estradiol joined to mechlorethamine, administered orally for palliative treatment of metastatic or progressive carcinoma of the prostate. It is used as estramustine phosphate sodium.
estramustine [es″trah-mus´tēn]
an antineoplastic agent containing estradiol joined to mechlorethamine; administered orally for palliative treatment of metastatic or progressive carcinoma of the prostate; used as estramustine phosphate sodium.
estramustine
Oncology A combination of estradiol and nitrogen mustard used in the palliative therapy of prostate CA. See Prostate CA.
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Docetaxel and estramustine compared with mitoxantrone and prednisone for advanced refractory prostate cancer.
A rapid PSA half-life following docetaxel chemotherapy is associated ... by Hanninen, Mikael; Venner, Peter; North, Scott / Canadian Urological Association Journal (CUAJ)
There are different activities but generally these drugs stabilise the overall microtubule structure and resist the depolymerization that occurs during mitosis, so the cells remain frozen or arrested at this (M) phase of the cell cycle An example of an antimicrotubule drug is Estramustine.
Conventional treatments: chemotherapy--a medical 'solution' by Bridgman, Karen E. / Australian Journal of Medical Herbalism
66-69) Neoadjuvant chemotherapy with estramustine also produces comparable outcome.
Neoadjuvant therapy: an emerging concept in oncology by Lo, Simon S. / Southern Medical Journal
 
 
 
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