estramustine


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estramustine

 [es″trah-mus´tēn]
an antineoplastic agent containing estradiol joined to mechlorethamine; administered orally for palliative treatment of metastatic or progressive carcinoma of the prostate; used as estramustine phosphate sodium.

estramustine

/es·tra·mus·tine/ (-mus´tēn) an antineoplastic containing estradiol joined to mechlorethamine, used for palliative treatment of metastatic or progressive carcinoma of the prostate; used as e. phosphate sodium.

estramustine

(ĕs′trə-mŭs′tēn′)
n.
A drug, C23H31Cl2NO3, that combines the actions of estrogen and nitrogen mustard in the treatment of prostate cancer.

estramustine

[es′trämus′tēn]
an antineoplastic agent containing estradiol joined to mechlorethamine, administered orally for palliative treatment of metastatic or progressive carcinoma of the prostate. It is used as estramustine phosphate sodium.

estramustine

Oncology A combination of estradiol and nitrogen mustard used in the palliative therapy of prostate CA. See Prostate CA.

estramustine

An alkylating anti-cancer drug. A brand name is Estracyt.
References in periodicals archive ?
2] every 21 days, plus oral estramustine, an estrogenic drug, 280 mg t.
Neither docetaxel or estramustine is likely to radically change the prognosis for men with advanced disease, but the findings are likely to shake many urologic oncologists out of their intellectual boxes.
Drugs that might interfere with the results of monitoring tests Antineoplastic drugs Other drugs Azacitidine Atropine Busulfan Chloral hydrate Chlorambucil Chlordiazepoxide Cisplatin Chlorpromazine Cyclophosphamide Cimetidine Cytarabine Diazepam Dacarbazine Dobutamine Dibromodulcitol Dopamine Estramustine Ephedrine Floxuridine Fentanyl Fludarabine Haloperidol Fluorouracil Hydroxyzine Ifosfamide Meperidine Lomustine Metoclopramide Mercaptopurine Midazolam Methotrexate Morphine Streptozocin Pentobarbital Thiopeta Phenylephrine Prochlorperazine Promethazine Ranitidine Scopolamine Secobarbital Temazepam
For men with hormone-refractory prostate cancer, the use of docetaxel (Taxotere, Rhone-Poulenc Rorer) plus the nitrogen mustard estramustine phosphate (Emcyt, Pharmacia & Upjohn) appears to help men whose prostate cancers no longer respond to treatment with synthetic estrogen and antiandrogens.
Aside from mitoxantrone and glucocorticoids, current trials are focusing on ketoconazole, estramustine phosphate, vinblastine, and suramin (Vogelzang et al.
Chemotherapeutic agents, including cyclophosphamide, doxorubicin, 5-fluorouracil, dacarbazine, cisplatin, estramustine, and streptozocin, alone or in combination, have produced disappointing overall response rates of approximately 30% (in those with mostly stable disease, with few complete or partial responses), with median survivals of 26 to 33 weeks.
Most notably, he served as the PI for a randomized trial comparing docetaxel and estramustine to mitoxantrone and prednisone in men with hormone refractory prostate cancer.
A parallel study comparing Taxotere and estramustine (Emcyt), an antineoplastic compound that contains estradiol and is approved for prostate cancer, to mitoxantrone and prednisone found about a 1.
4C only during treatment with Taxane/ estramustine and was not detected before or after treatment.
A multifold increase of [Beta]III transcript expression has been shown in nonneuronal tumors, such as non-small cell lung cancer, and in ovarian and prostate cancer cell lines, particularly in those exhibiting resistance to a class of antimicrotubule (microtubule-polymerizing) drugs, such as estramustine and paclitaxel (Taxol).
Estramustine disodium phosphate Sales volume and market share
Use of estramustine in combination with other cytotoxic agents is not recommended due to the increased risk of clinically important toxicities.