Mach

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Mach

(mahk),
Ernst, scientist in Hapsburg Empire, 1838-1916. See: Mach band, Mach number.

CASP8

A gene on chromosome 2q33-q34 that encodes a protein belonging to the cysteine-aspartic acid protease (caspase) family which, once activated by proteolytic processing, plays a central role in the execution phase of cell apoptosis, as well as various stages of embryological development. CASP8 is an initiator-type caspase, which is activated by, and interacts with, upstream adaptor molecules through CARD and DED protein–protein interaction domains; it is involved in the programmed cell death induced by Fas and various apoptotic stimuli. It is highly expressed in peripheral blood leukocytes and in the spleen, thymus and liver.

Molecular pathology
CASP8 has been detected in the insoluble fraction of affected brain regions in Huntington disease, suggesting a role in neurodegenerative diseases.
References in periodicals archive ?
Briefly describe a contribution to logical positivism made by each of the following individuals: Gottlob Frege, Bertrand Russell, Ernst Mach, Ludwig Wittgenstein.
Helmholtz, in spite of his acknowledged achievements, was not himself immune to criticism from renowned contemporaries such as Wilhelm Wundt (a former student), Ernst Mach, and William James.
This book is part of a multi-volume study of the life and thought of scientist and philosopher Ernst Mach (1838-1916).
Several years ago, Peter Krehl of the Ernst Mach Institute in Freiburg, Germany, and his colleagues examined a cracking whip with a photographic method that shows shock waves.
Wallace's work dispels the myth of a sharp distinction between medieval and modern science, a myth fostered in part by the positivist Ernst Mach, who, for ideological reasons, ignored Galileo's Aristotelian and scholastic sources.
In the 1870s Ernst Mach had proposed the principle of mechanics that ".
This volume collects writings for and against positions taken by Austrian physicist and philosopher Ernst Mach (1838-1916).