In conclusion, this 76-year-old patient with bilateral medullary sclerosis of long bones, mildly elevated RF, the most likely diagnosis is Erdheim-Chester disease.
Successful treatment of Erdheim-Chester disease, a non-Langerhanscell histiocytosis, with interferon-alpha.
is a rare, multisystem, non-Langerhans form of histiocytosis.
NASDAQ: TROV), a developer of cell-free molecular diagnostics, today announced that the multi-disciplinary clinical consensus guidelines for Erdheim-Chester disease
(ECD), recently published online in the journal Blood, reference the ability of the Company's precision cancer monitoring technology to detect actionable oncogene mutation status and monitor patients during treatment.
is an idiopathic condition of lymphohistiocytic infiltration in the orbit as well as internal organs including the heart, lungs, retroperitoneum, bones, and other tissues.
The poster, titled "Droplet digital PCR detection and longitudinal monitoring of BRAF mutations in cell-free urinary DNA of patients with metastatic cancers or Erdheim-Chester disease
," will be displayed at the AACR Annual Meeting until noon PDT on Tuesday, April 8, and subsequently available through Trovagene's website.
Another systemic histiocytic disease that can involve the CNS and produce lesions mimicking a primary brain tumor is Erdheim-Chester disease
Title: Droplet digital PCR detection and longitudinal monitoring of BRAF mutations in cell-free urinary DNA of patients with metastatic cancers or Erdheim-Chester disease
Presenter: Filip Janku, M.
The differential diagnostic possibilities include lesions, both nonneoplastic and neoplastic lesions, such as Erdheim-Chester disease
, sinus histiocytosis with massive lymphadenopathy, giant cell tumor of bone, eosinophilic granuloma, malignant fibrous histiocytoma, or metastatic renal cell carcinoma.