ERBB3

(redirected from ErbB-3)

ERBB3

A gene on chromosome 12q13 that encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases which binds and is activated by neuregulins and NTAK.

Molecular pathology
ERBB3 amplification and overexpression has been described in multiple cancers, including prostate, bladder and breast.
References in periodicals archive ?
Ligand binding to the four closely related members of this RTK family -epidermal growth factor receptor (EGFR, also known as ErbB-1 or HER1), ErbB-2 (HER2), ErbB-3 (HER3), and ErbB-4 (HER4)-induces the formation of receptor homo- and heterodimers and the activation of the intrinsic kinase domain, resulting in phosphorylation on specific tyrosine residues (pY) within the cytoplasmic tail.
Competitive-differential polymerase chain reaction for gene dosage estimation of erbB-1 (egfr), erbB-2, and erbB-3 oncogenes.
80,81] Since this transmembrane receptor has homology to other family members (epidermal growth factor receptor [EGFR], erbB-3, and erbB-4), clinical tests must be specific for erbB-2 (as opposed to cross-reacting with homologous family members) and specific enough to detect amplification (increased gene copy number) or protein overexpression above the normal level.