point of no return

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point of no return

A colloquial term for a critical biochemical event that indicates lethal, irreversible changes in cells following ischemic cell injury.
See also: point
References in periodicals archive ?
With nine major airlines becoming Class A shareholders in Equitime by contributing $5 million each in start-up capital--and smaller subgroups contributing proportionally--Equitime projects gross written premium of about $450 million, which would immediately cover its full $300 million retention.
Indeed, if the focus of terror does shift away from airliners, then Equitime could prove to be a best-case scenario, meaning great business for Vermont and a way for the government to back away from aviation reinsurance in only a few years.
There has been talk that the Equitime risk-retention group would be domiciled in Vermont, the largest captive domicile in the United States and third-largest in the world.