epoetin


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epoetin

 [e-po´ĕ-tin]
a form of human erythropoietin produced by recombinant technology and having the same amino acid sequence and mechanism of action as endogenous erythropoietin. Used in treatment of anemia from various causes, including chronic renal failure, zidovudine therapy, and cancer chemotherapy; also used prior to surgery in anemic patients to reduce the need for blood transfusion. Administered intravenously or subcutaneously. It is available in two forms, designated epoetin alfa (the form used in the United States) and epoetin beta (used in various other countries). Called also recombinant human erythropoietin.

epoetin

/epo·e·tin/ (e-po´ĕ-tin) a recombinant form of human erythropoietin, used as an antianemic; in the United States the form used is e. alfa but e. beta may be used elsewhere.

EPO

A gene on chromosome 7q22 that encodes erythropoietin, a secreted, glycosylated cytokine found in the plasma, which regulates red cell production by promoting erythroid differentiation and initiating haemoglobin synthesis. Erythropoietin plays a neuroprotective role in response to brain injury and is antiapoptotic.

Molecular pathology
Genetic variability of EPO has been linked to microvascular complications of diabetes type 2, including diabetic retinopathy, nephropathy leading to end-stage renal disease, and neuropathy

epoetin

Human erythopoetin made by genetic engineering for use as a drug to treat severe anaemia Brand names are Eprex and Neorecormon.
References in periodicals archive ?
To determine whether there was a differential impact of patient characteristics on facility-level injectable drug dosing, we analyzed the effect of the patient demographic and clinical characteristics, including patient age, gender, race, diabetic status, and response to epoetin therapy (often viewed as a surrogate of patient underlying health state), on facility drug use.
Observational studies have reported an increase in hemoglobin levels with the administration of ascorbic acid (vitamin C) due to the role oxidative stress can play in hyporesponsiveness to epoetin alfa (Lin, Hsu, Yang, & Huang, 2003).
This was a retrospective study of epoetin alfa drug costs during a six-month MDV usage period (July to December of 2007, hereafter referred to as period one) versus a six-month PFS usage period (July to December of 2008, three months post-conversion, hereafter referred to as period two) (see Figure One).
When the patient responses were stratified by ESA treatment, sc epoetin beta administration was associated with the lowest degree of pain or discomfort while sc darbepoetin alfa was associated with the highest degree of pain or discomfort (Figure 1).
Patients received placebo or an intravenous dose of 40,000 U per day of epoetin alfa for 3 days, "considerably" higher than the recommended dose for anemia.
SC epoetin was administered up to three times weekly, compared to CERA dosed either once every two weeks or once every four weeks.
epoetin alfa does increase hemoglobin among chronic-anemic elderly patients" Agnihotri says.
The instructions were to assign each image to the epoetin alfa or the placebo group.
She reported on 83 breast cancer patients randomized to either 40,000 units of subcutaneous epoetin alfa once weekly or placebo during four cycles of adjuvant chemotherapy over a 3-month period.
M2 PHARMA-May 29, 2017-USFDA Oncologic Drugs Advisory Committee recommends approval of Pfizer's epoetin alfa biosimilar
M2 EQUITYBITES-May 29, 2017-USFDA Oncologic Drugs Advisory Committee recommends approval of Pfizer's epoetin alfa biosimilar