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a form of human erythropoietin produced by recombinant technology and having the same amino acid sequence and mechanism of action as endogenous erythropoietin. Used in treatment of anemia from various causes, including chronic renal failure, zidovudine therapy, and cancer chemotherapy; also used prior to surgery in anemic patients to reduce the need for blood transfusion. Administered intravenously or subcutaneously. It is available in two forms, designated epoetin alfa (the form used in the United States) and epoetin beta (used in various other countries). Called also recombinant human erythropoietin.
epoetin/epo·e·tin/ (e-po´ĕ-tin) a recombinant form of human erythropoietin, used as an antianemic; in the United States the form used is e. alfa but e. beta may be used elsewhere.
EPOA gene on chromosome 7q22 that encodes erythropoietin, a secreted, glycosylated cytokine found in the plasma, which regulates red cell production by promoting erythroid differentiation and initiating haemoglobin synthesis. Erythropoietin plays a neuroprotective role in response to brain injury and is antiapoptotic.
Genetic variability of EPO has been linked to microvascular complications of diabetes type 2, including diabetic retinopathy, nephropathy leading to end-stage renal disease, and neuropathy