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epitope
(redirected from Epitopes)

    Also found in: Dictionary/thesaurus, Encyclopedia, Wikipedia 0.02 sec.
epitope /ep·i·tope/ (ep´ĭ-tōp) an antigenic determinant (see under determinant ) of known structure.
ep·i·tope (p-tp)
n.
The surface portion of an antigen capable of eliciting an immune response and of combining with the antibody produced to counter that response.
epitope
[ep′itōp]
Etymology: Gk epi + topos, place
epitope
see antigenic determinant.
continuous epitope
contiguous amino acid sequences in a linear array.
discontinuous epitope
one in which amino acids are in close proximity in the folded protein, but distant when unfolded.
epitope
Immunology Any site on a molecule–an antigenic determinant that can evoke antibody formation. See Idiotype, Immunogenicity.


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? Mentioned in ? References in periodicals archive
 
Mutations that occur within the immunodominant epitopes of hepatitis B surface antigen (HBsAg) allow mutant virus to propagate in the presence of a neutralizing immune response, while wild-type virus is reduced to undetectable levels.
Detecting hepatitis B surface antigen mutants by Coleman, Paul F. / Emerging Infectious Diseases
The linear IgE-binding epitopes of the Ara h2 allergen have been mapped using overlapping peptides and serum IgE from a population of patients known to be sensitized to peanuts.
Protein digestibility and relevance to allergenicity. (Genetically ... by Hinton, Dennis M. / Environmental Health Perspectives
A useful approach may involve the use of an expression library, whereby the genome of a pathogen is fragmented and the pieces of DNA captured to create a pathogen library that represents most of the T cell epitopes that exist for that pathogen.
Generation of multivalent genome-wide T cell responses in HLA-A*0201 ... by Barry, Michael A. / Research Initiative/Treatment Action!
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