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epitope
(redirected from Epitopes)

    Also found in: Dictionary/thesaurus, Encyclopedia, Wikipedia 0.29 sec.
epitope /ep·i·tope/ (ep´i-top) an antigenic determinant (see under determinant ) of known structure.
ep·i·tope (p-tp)
n.
The surface portion of an antigen capable of eliciting an immune response and of combining with the antibody produced to counter that response.
epitope
see antigenic determinant.
continuous epitope
contiguous amino acid sequences in a linear array.
discontinuous epitope
one in which amino acids are in close proximity in the folded protein, but distant when unfolded.
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Mutations that occur within the immunodominant epitopes of hepatitis B surface antigen (HBsAg) allow mutant virus to propagate in the presence of a neutralizing immune response, while wild-type virus is reduced to undetectable levels.
Detecting hepatitis B surface antigen mutants by Coleman, Paul F. / Emerging Infectious Diseases
The linear IgE-binding epitopes of the Ara h2 allergen have been mapped using overlapping peptides and serum IgE from a population of patients known to be sensitized to peanuts.
Protein digestibility and relevance to allergenicity. (Genetically ... by Hinton, Dennis M. / Environmental Health Perspectives
A useful approach may involve the use of an expression library, whereby the genome of a pathogen is fragmented and the pieces of DNA captured to create a pathogen library that represents most of the T cell epitopes that exist for that pathogen.
Generation of multivalent genome-wide T cell responses in HLA-A*0201 ... by Barry, Michael A. / Research Initiative/Treatment Action!
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