EPCAM

(redirected from Epithelial glycoprotein)

EPCAM

A gene on chromosome 2p21 that encodes a carcinoma-associated antigen expressed on most normal epithelial cells and gastrointestinal carcinomas, which functions as a homotypic calcium-independent cell adhesion molecule. EPCAM is thought to function as a relay molecule between intestinal epithelial cells and intraepithelial lymphocytes at the mucosa, providing an immune barrier to infection. It is of interest in oncology as a target for cancer immunotherapy. It upregulates expression of FABP5, MYC and cyclins A and E.

Molecular pathology
Defects in EPCAM cause congenital tufting enteropathy (diarrhoea type 5).
References in periodicals archive ?
Results were negative for carcinoembrionary antigen and the epithelial glycoprotein Ber-EP4, whereas results were positive for the mesothelial markers cytokeratins, calretinin, epithelial membrane antigen, and HBME-1, thus leading to the correct diagnosis of peritoneal epithelial mesothelioma.
Staining for the carcinoembrionary antigen (CEA) and the epithelial glycoprotein Ber-EP4 was negative, whereas results for the mesothelial markers cytokeratins, calretinin (Figure 2), epithelial membrane antigen (EMA), and HBME-1 (Figure 3) were positive, leading to the diagnosis of peritoneal epithelial mesothelioma.
A new method for the histochemical demonstration of O-acyl sugar in human colonic epithelial glycoproteins.