EPCAM

(redirected from Epithelial cell surface antigen)

EPCAM

A gene on chromosome 2p21 that encodes a carcinoma-associated antigen expressed on most normal epithelial cells and gastrointestinal carcinomas, which functions as a homotypic calcium-independent cell adhesion molecule. EPCAM is thought to function as a relay molecule between intestinal epithelial cells and intraepithelial lymphocytes at the mucosa, providing an immune barrier to infection. It is of interest in oncology as a target for cancer immunotherapy. It upregulates expression of FABP5, MYC and cyclins A and E.

Molecular pathology
Defects in EPCAM cause congenital tufting enteropathy (diarrhoea type 5).
References in periodicals archive ?
Capturing CTCs lacking EpCAM expression has involved the use of cocktails of antibodies against various other epithelial cell surface antigens [human epidermal growth factor receptor 2 (HER2), mucin-1 (MUC1), epidermal growth factor receptor (EGFR), folate-binding protein receptor, TROP-2] and against mesenchymal or stem cell antigens (c-MET, N-cadherin, CD318, and mesenchymal stem cell antigen) (10).

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