CDH1

(redirected from Epithelial cadherin)

CDH1

A gene on chromosome 16q22.1 that encodes a calcium-dependent cell–cell adhesion glycoprotein (cadherin), which is involved in regulating cell–cell adhesions, mobility and proliferation of epithelial cells.

Molecular pathology
CDH1 loss-of-function mutations correlate with gastric, breast, colorectal, thyroid and ovarian cancer, and they are thought to contribute to cancer progression by increasing proliferation, invasion and/or metastasis. CDH1 mutation causes hereditary diffuse gastric cancer and an increased susceptibility to endometrial and ovarian cancers.
References in periodicals archive ?
Moreover, exposure to the matrix caused all of the cancer cells to increase their expression of the protein epithelial cadherin (i.
Downregulation of epithelial cadherin is required to initiate metastatic outgrowth of breast cancer.
4, 5) Formation of SRCs in diffuse adenocarcinoma and the propensity of SRCs to scatter in vitro may be related to altered epithelial cadherin and [alpha] -catenin.