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epirubicin

   Also found in: Wikipedia 0.02 sec.
epirubicin /epi·ru·bi·cin/ (-roo´bĭ-sin) an antineoplastic with action similar to doxorubicin; used in the treatment of various carcinomas, leukemia, lymphoma, and multiple myeloma.
epirubicin,
an antibiotic antineoplastic.
indications It is used as an adjuvant therapy to treat breast cancer with axillary node involvement following resection.
contraindications Factors that prohibit its use include severe hepatic disease, baseline neutrophil count less than 1500 cells/mm3, severe myocardial insufficiency, recent myocardial infarction, pregnancy, lactation, systemic infections, and known hypersensitivity to this drug, anthracyclines, or anthracenediones.
adverse effects Life-threatening effects are thrombocytopenia, leukopenia, anemia, neutropenia, secondary acute myelocytic leukemia, sinus tachycardia, premature ventricular contractions, bradycardia, and extrasystoles. Other serious adverse effects include increased blood pressure and chest pain. Common side effects include nausea, vomiting, anorexia, mucositis, diarrhea, amenorrhea, hot flashes, hyperuricemia, rash, necrosis at the injection site, reversible alopecia, infection, febrile neutropenia, lethargy, fever, and conjunctivitis.

epirubicin
an anthracycline antibiotic similar to doxorubicin, used as an antineoplastic agent.


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Preliminary report of the Asian-Oceanian Clinical Oncology Association randomized trial comparing cisplatin and epirubicin followed by radiotherapy versus radiotherapy alone in the treatment of patients with locoregionally advanced nasopharyngeal carcinoma.
including, Amifostine, Carboplatin USP, Cisplatin USP, Doxorubicin HCl USP, Epirubicin HCl EP, Etoposide USP, Fludarabine Phosphate, Gemcitabine HCl USP, Ifosfamide USP, Irinotecan HCl 3H2O, Mitoxantrone HCl USP/PhEur and Thiotepa USP.
Neoadjuvant chemotherapy with sequential weekly nanoparticle albumin-bound paclitaxel (ABI-007, ABRAXANE) followed by 5-fluorouracil, epirubicin and cyclophosphamide (FEC) in locally advanced breast cancer (LABC): a phase II trial of the NSABP Foundation Research Group (Poster Number: 3068)
 
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