major basic protein

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major basic protein

a cytotoxic and proinflammatory mediator found in eosinophil granules.

major basic protein

An 11-kD major cytotoxic and helminthotoxic protein encoded by PRG2 on chromosome 11q12, which forms a characteristic crystalloid and is found in the granules of eosinophils and other myeloid cells. It induces non-cytolytic histamine release from human basophil, and is involved in antiparasitic defence and immune hypersensitivity reactions.

The adjectival “basic” derives from MBP’s isoelectric point of greater than pH 10. MBP is capable of killing parasites, as well as host cells; it causes bronchial epithelial damage and a wheal and flare response when injected subcutaneously, and it has been linked to asthma.
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Pregnancy-associated plasma protein A and its endogenous inhibitor, the proform of eosinophil major basic protein (proMBP), are related to complexstenosis morphology in patients with stable angina pectoris.
Isolation and characterization of circulating complex between human pregnancy-associated plasma protein-A and proform of eosinophil major basic protein.
Proteinase inhibition by proform of eosinophil major basic protein (pro-MBP) is a multistep process of intra- and intermolecular disulfide rearrangements.
Identification of angiotensinogen and complement C3dg as novel proteins binding the proform of eosinophil major basic protein in human pregnancy serum and plasma.
Covalent interaction between proform of eosinophil major basic protein (proMBP) and pregnancy-associated plasma protein-A (PAPP-A) is a cell-mediated event and required for proMBP inhibition of the catalytic activity of PAPP-A.
Cloning and sequence analysis of the human gene encoding eosinophil major basic protein.
Increases of plasma eosinophil major basic protein levels late in pregnancy predict onset of labor.

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