enzyme inhibitor

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enzyme inhibitor

a molecule that prevents an enzyme from catalysing a reaction. Such inhibitors can compete with the normal substrate (see COMPETITIVE INHIBITION or can block the active site, preventing entry of the substrate (see NONCOMPETITIVE INHIBITION). Inhibition may be reversible or irreversible. Enzyme inhibitors often form part of a FEEDBACK MECHANISM to regulate a biochemical pathway.
References in periodicals archive ?
We look forward to beginning an additional pivotal trial for epacadostat, as we seek to position IDO1 enzyme inhibition as a key component of combination immunotherapy.
Phytochemical analysis and enzyme inhibition assay of Aerva javanica for ulcer.
Potential of azadirachtin and neem (Azadirachta indica) based saponins as biopesticides for in vitro insect pests cellulase (Beta-1, 4- Endoglucanase) enzyme inhibition and in vivo repellency on Tribolium castaneum.
Hydro distilled essential oil from buds of Syzygium aromaticum was investigated for antioxidant and enzyme inhibition activities.
i]) were first estimated by graphical methods, such as Lineweaver-Burk, Dixon and secondary reciprocal plots, and were finally determined by non-linear least squares regression analysis, based on the best enzyme inhibition model [18] using the WinNonlin software.
Khan AW (2012) Phytochemical analysis and enzyme inhibition assay of Aervajavanica for ulcer.
For example, penicillin antibiotics are natural products that specifically kill bacteria by enzyme inhibition (see Figure 2).
Angiotensin converting enzyme inhibition by means of angiotensin converting enzyme inhibitors may significantly affect renal hemodynamic conditions and effective renal plasma flow in patients with diffuse renal parenchymal disease and in individuals with essential hypertension, and the extent of the hemodynamic changes depends also on the functional status of the kidney.
Mechanistically, cherries exhibit relatively high antioxidant activity, low glycemic response, COX 1 and 2 enzyme inhibition, and other anti-carcinogenic effects in vitro and in animal experiments.
26 Angiotensin converting enzyme inhibition has been shown to improve insulin sensitivity and glycemic control in diabetic patients27 and to result in a 14% relative reduction in the incidence of new-onset type 2 diabetes.
Omiand T, de Lemos JA, Sabatine MS, Christophi CA, Rice MM, Jablonski KA, et al, and the Prevention of Events with Angiotensin Converting Enzyme Inhibition (PEACE) Trial Investigators.
Treatment of ALP with Cadmium also led to enzyme inhibition (as measured by decrease in the rate of pNPP hydrolysis figure 1 and table 1).