This navigation tool rests deep in the brain, in a small, sausage-shaped region called the entorhinal
Interaction between paired-pulse facilitation and long-term potentiation in the projection from hippocampal area CAI to the entorhinal
Two MRI brain scans -- one to assess the thickness of the right entorhinal
cortex and another to measure the volume of the hippocampus, both of which are important for memory.
revealed that women with low libido had lower than normal activity in the entorhinal
cortex, an area of the brain involved in storing positive emotional memories.
Studies on London cab drivers have shown that the first thing they do when they work out a route is calculate which direction they need to head in," lead author Dr Hugo Spiers said, adding, "We now know the entorhinal
cortex is responsible for such calculations and the quality of the signals from this region seems to determine how good someone's navigational skills will be.
Indeed, we have recently shown that mature APP is significantly reduced in human cerebellum compared to entorhinal
cortex and hippocampus - the most susceptible human brain regions to AD.
There was no increased activity in another hippocampal region, the entorhinal
cortex, which is impaired early in Alzheimer's disease.
May-Britt and Edvard Moser were mapping the connections to the hippocampus in rats moving in a room when they discovered an astonishing pattern of activity in a nearby part of the brain called the entorhinal
Map of outside world Nearly a decade later, the Moser team discovered cells, in the entorhinal
cortex region in brains of rats, which function as a navigation system.
18]F]T807 binding in the entorhinal
cortex (P less than .
They also measured the size of two brain structures deep in the temporal lobes - the entorhinal
cortex and the hippocampus (which are important for memory) - and amyloid deposits in the brain.
The study, funded by the Wellcome Trust, showed that the brain region called entorhinal
cortex calculates the straight-line to the destination, while the posterior hippocampus region became active when keeping track of the path needed to reach the destination.