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endothelium-derived |
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endothelium-derived derived from endothelium. endothelium-derived vasoactive substances substances produced by or released from endothelial cells which regulate vascular smooth muscle or other regulatory mechanism; include prostacyclin and other prostanoids, angiotensin, and relaxing or constricting factors. endothelium-derived constricting factor vasoconstrictive peptides isolated from vascular endothelial cells which are actively vasoconstrictive; endothelin (ET) is the most active of them. endothelium-derived relaxing factor several are known; nitrous oxide is one of the chief mediators, probably derived from l-arginine. |
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These effects are counterbalanced by the pulmonary vascular endothelium's ability to release endothelium-derived relaxing factors (56), which includes nitric oxide (NO) (57,58) and prostacyclin (59). The researchers speculate that people with healthy blood vessels react to epinephrine's vessel-constricting message by stepping up production of a natural, nitroglycerine-like substance called endothelium-derived relaxing factor (EDRF). |
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Endothelium-derived relaxing factor
