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endothelin |
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endothelin (ET) [-thē′lin] any of a group of vasoconstrictive peptides produced by endothelial cells. Three known endothelins, designated ET-1, ET-2, and ET-3, are chemically related to asp venom. ET-1 is the most potent vasoconstrictor yet discovered, being 10 times stronger than the second-most potent vasoconstrictor known, angiotensin II. endothelin see endothelium-derived constricting factor. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Mature endothelins have a half-life on the order of minutes due to rapid clearance from the bloodstream through binding to G-protein-coupled endothelin B (ETB) receptors in caveolae on the surface of lung capillary endothelial cells (Yamaguchi et al. As discussed previously, prostaglandins, nitric oxide and endothelins are all important mediators of pulmonary vascular homeostasis, and have been shown to be affected by this disease. |
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