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ETs are a family of peptide hormones with three members, endothelin-1 (ET-1), endothelin-2 (ET-2) and endothelin-3 (ET-3) (Inoue et al.
Cross-reactivity of the system for endothelin-1 is 100%, but less than 7% for both endothelin-2 and endothelin-3 according to the manufacturer.
Until now, three isoforms, endothelin-1, endothelin-2, and endothelin-3, have been isolated, each consisting of 21 amino acid residues [2].
Endothelin-1 and endothelin-3 induce chemotaxis and replication of pulmonary fibroblasts.

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