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endothelin |
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endothelin (ET) [-thē′lin] any of a group of vasoconstrictive peptides produced by endothelial cells. Three known endothelins, designated ET-1, ET-2, and ET-3, are chemically related to asp venom. ET-1 is the most potent vasoconstrictor yet discovered, being 10 times stronger than the second-most potent vasoconstrictor known, angiotensin II. endothelin see endothelium-derived constricting factor. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Endothelin-1 (ET-1) is implicated directly in the progression of cardiovascular diseases (Luscher and Barton 2000), and a number of polymorphisms for ET-1 and endothelin receptor genes have been identified that are associated with increased risk for pulmonary and cardiovascular conditions (Charron et al. Another class of agents used in the treatment of pulmonary artery hypertension are the endothelin-1 receptor antagonists. These endothelial cells--and their counterparts in people--secrete a compound called endothelin-1 that constricts blood vessels. |
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