1994) Lysosome biogenesis requires Rab9 function and receptor recycling from endosomes
to the trans-Golgi network.
Increased neuronal endocytosis and protease delivery to early endosomes
in sporadic Alzheimer's disease: neuropathologic evidence for a mechanism of increased [Beta]-amyloidogenesis.
However, he says, the new findings suggest that in a dividing cell, endosomes
with small asbestos fibers would continue to scoot along the tubule roadway, but away from the region of the dividing chromosomes.
Our reports provided evidence that SLO is critical for bacterial escape from endosomes
into the cytosol, followed by autophagic clearance of internalized GAS organisms.
One of the mechanisms regulating cellular cholesterol homeostasis is export from endosomes
by Niemann-Pick disease proteins (NPC1 and NPC2) (Cheruku et al, 2006).
2+] has also been shown to accumulate in endosomes
, lysosomes, secretory granules, the Golgi apparatus, and nucleus (for review, see Laude and Simpson 2009).
At the same time, the cells use endocytosis to carefully adjust the quantity of signal molecules on the cell membrane and in the endosomes
- endocytosis and signalling pathways thus influence each other.
Class 5 sequence variations produce receptors that bind ligands in coated pits but fail to release them at acidic pH in endosomes
, and thus do not recycle to the cell surface (13).
This assumption rests on the fact that one of the constituent drugs, Ephedrae Herba extract, was reported to inhibit the growth of influenza A PR8 virus in a transient association with the disappearance of acidified endosomes
and lysosomes at an early phase of infection in MDCK cells (Mantani et al.
Ehrlichia chaffeensis inclusions are [ILLEGIBLE TEXT] endosomes
which selectively accumulate transferrin receptor.
The PathHunter[TM] Activated GPCR Internalization technology is a non-imaging, non-antibody based platform that provides a direct and quantitative measurement of internalized GPCR localized to intracellular endosomes
allowing the fate of unlabeled, activated GPCRs to be monitored in live cells.
EGFR is overexpressed in many cancers, and its activation is related to the tumor microenvironment; for example, oxidative stress-mediated activation of EGFR leads to failure of EGFR to undergo entry into early endosomes
for subsequent degradation, resulting in prolonged activation of EGFR signaling, tumorigenesis, and malignancy [15,16].