endopeptidase

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Related to Endopeptidases: Exopeptidases

endopeptidase

 [en″do-pep´tĭ-dās]
any peptidase that catalyzes the cleavage of internal bonds in a polypeptide or protein. Inhibition of the action of endopeptidases (proteases) in viruses causes formation of noninfectious particles; certain antiviral drugs work in this way (see protease inhibitors). Called also protease and proteinase.

en·do·pep·ti·dase

(en'dō-pep'ti-dās),
An enzyme that catalyzes the hydrolysis of a peptide chain at points well within the chain, not near either terminus; for example, pepsin, trypsin. Compare: exopeptidase.
Synonym(s): proteinase

endopeptidase

/en·do·pep·ti·dase/ (-pep´tĭ-dās) protease; any peptidase that catalyzes the cleavage of internal bonds in a polypeptide or protein.

endopeptidase

(ĕn′dō-pĕp′tĭ-dās′, -dāz′)
n.
Any of a large group of enzymes that catalyze the hydrolysis of peptide bonds in the interior of a polypeptide chain or protein molecule.

endopeptidase

[en′dōpep′ti·dās]
Etymology: Gk, endon, within + Gk, peptein, to digest + ase, enzyme suffix
any peptidase that catalyzes the cleavage of internal peptide bonds in a polypeptide or protein. Endopeptidases are divided into subclasses on the basis of catalytic mechanism and comprise the serine endopeptidases, cysteine endopeptidases, aspartic endopeptidases, metalloendopeptidases, and other endopeptidases.

en·do·pep·ti·dase

(en'dō-pep'ti-dās)
An enzyme catalyzing the hydrolysis of a peptide chain at points well within the chain, not near termini (e.g., pepsin, trypsin).
Compare: exopeptidase

endopeptidase

or

proteinase

a type of PROTEASE (protein-splitting enzyme) that hydrolyses peptide bonds between particular amino acids located inside the chain, but not at the ends. There are three major endopeptidases in the mammalian gut: PEPSIN (stomach); TRYPSIN and CHYMOTRYPSIN (pancreas). Such enzymes are responsible for the first stage of protein digestion; other proteases called EXOPEPTIDASES complete the digestion of protein in the ILEUM.

endopeptidase

a peptidase capable of acting on any peptide linkage in a peptide chain.
References in periodicals archive ?
Because of its exopeptidase activity, it has been implicated in the metabolism of metenkephalin (18) and angiotensin (Ang) III (17); its endopeptidase activity is also thought to be involved in neurotensin metabolism (19).
Preferential cleavage of des-31,32-proinsulin over intact proinsulin by the insulin secretory granule type II endopeptidase.
In addition to cysteine proteases, other types of endopeptidases have been suggested to be involved in flower senescence.
OXFORD, England, March 2, 2011 /PRNewswire/ -- Syntaxin, a biotechnology company developing novel biopharmaceuticals to control cell secretion, today announces its partner Allergan, Inc has initiated two Phase II trials to evaluate the safety and efficacy of its re-targeted endopeptidase drug candidate AGN-214868.
in the nerve cells, has been utilized in a novel 'second generation' ELISA, the endopeptidase assay (117).
One way to control inflammation is through the inhibition of matrix metalloproteases (MMP), which are naturally-occuring zinc-dependent endopeptidases found in most mammals.
The matrix metalloproteinases (MMPs) are a family of zinc- and calcium-dependent endopeptidases with a central role in inflammation and combined ability to degrade components of connective tissue matrices (Murphy and Docherty 1992).
1) Though there is no difference in fecal microflora in patients with PA, it is thought that bacterial endopeptidases, exotoxins, and intestinal lysozymes act as irritating agents.
Protease inhibitors may restrict insect development by inhibiting the activity of endopeptidases elastase and trypsin.
For the endopeptidases, the highest value was for trypsin in the stomach during premolt and in the midgut gland during intermolt.
Comparative molecular analysis of two asparaginy endopeptidases and encoding genes from Fasciolagigantica.