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ligand
(redirected from Endogenous ligand)

   Also found in: Encyclopedia, Wikipedia, Hutchinson 0.03 sec.
ligand /li·gand/ (li´gand) (lig´and) an organic molecule that donates the necessary electrons to form coordinate covalent bonds with metallic ions. Also, an ion or molecule that reacts to form a complex with another molecule.
li·gand (lgnd, lgnd)
n.
An ion, a molecule, or a molecular group that binds to another chemical entity to form a larger complex.

ligand
[lig′ənd, lī′gənd]
Etymology: L, ligare, to bind
1 a molecule, ion, or group bound to the central metal atom of a chemical compound, such as the oxygen molecule in oxyhemoglobin, which is bound to the central iron atom.
2 an organic molecule attached to a specific site on a cell surface or to a tracer element. The binding is reversible in a competitive binding assay. It may be the analyte or a cross-reactant. Examples include vitamin B12, a ligand with intrinsic factor as the binding protein, and various antigens, which are ligands with antibody-binding proteins.

ligand
(līgnd),
n 1. a molecule, ion, or group bound to the central atom of a chemical compound, such as the oxygen molecule in hemoglobin, which is bound to the central iron atom.
2. an organic molecule attached to a specific site on a surface or to a tracer element.

ligand
an organic molecule that donates the necessary electrons to form coordinate covalent bonds with metallic ions. Also, an ion or part of a molecule that specifically binds to form a complex with another molecule.


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? Mentioned in ? References in periodicals archive
 
The predominance of phytoestrogens as potent agents for ER and NodD signaling further supports the theory that an evolutionarily ancient or ancestral ER may have recognized and responded to phytoestrogens even before the emergence of the natural endogenous ligand [E.
Eight peptides were shown to activate six different GPCRs in a concentration-dependent manner, including some for which there are no known endogenous ligands.
The novel concept of developing allosteric modulators acting on a regulatory site rather than on the endogenous ligand site provides a meaningful way of enhancing the potency of the endogenous ligand and developing compounds with higher specificity and efficacy.
 
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