ligand

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ligand

 [li´gand, lig´and]
an organic molecule that donates the necessary electrons to form coordinate covalent bonds with metallic ions. Also, an ion or molecule that reacts to form a complex with another molecule.

lig·and

(lig'and, lī'gand),
1. Any individual atom, group, or molecule attached to a central metal ion by multiple coordinate bonds, for example, the porphyrin portion of heme, the corrin nucleus of the B12 vitamins.
2. An organic molecule attached to a tracer element, for example, a radioisotope.
3. A molecule that binds to a macromolecule, for example, a ligand binding to a receptor.
4. The analyte in competitive binding assays, such as radioimmunoassay.
5. An atom or group covalently attached to a specified carbon atom in an organic molecule.
[L. ligo, to bind]

ligand

/li·gand/ (li´gand) (lig´and) an organic molecule that donates the necessary electrons to form coordinate covalent bonds with metallic ions. Also, an ion or molecule that reacts to form a complex with another molecule.

ligand

(lī′gənd, lĭg′ənd)
n.
An ion, molecule, or molecular group that binds to another chemical entity to form a larger complex.

ligand

[lig′ənd, lī′gənd]
Etymology: L, ligare, to bind
1 a molecule, ion, or group bound to the central metal atom of a chemical compound, such as the oxygen molecule in oxyhemoglobin, which is bound to the central iron atom.
2 an organic molecule attached to a specific site on a cell surface or to a tracer element. The binding is reversible in a competitive binding assay. It may be the analyte or a cross-reactant. Examples include vitamin B12, a ligand with intrinsic factor as the binding protein, and various antigens, which are ligands with antibody-binding proteins.

li·gand

(lī'gand)
1. An organic molecule attached to a central metal ion by multiple coordinate bonds.
2. An organic molecule attached to a tracer element, e.g., a radioisotope.
3. A molecule that binds to a macromolecule, e.g., a ligand binding to a receptor.
4. The analyte in competitive binding assays, such as radioimmunoassay.
[L. ligo, to bind]

ligand

A MOLECULE or ION that binds to a central chemical entity by non-covalent bonds. A general term for any molecule that is recognized by a surface receptor.

ligand

a molecule able to bind to a specific ANTIBODY and used to distinguish closely similar types of antibody.

li·gand

(lī'gand)
1. Any individual atom, group, or molecule attached to a central metal ion by multiple coordinate bonds.
2. An organic molecule attached to a tracer element.
3. A molecule that binds to a macromolecule.
[L. ligo, to bind]

ligand

(līgənd),
n 1. a molecule, ion, or group bound to the central atom of a chemical compound, such as the oxygen molecule in hemoglobin, which is bound to the central iron atom.
2. an organic molecule attached to a specific site on a surface or to a tracer element.

ligand

an organic molecule that donates the necessary electrons to form coordinate covalent bonds with metallic ions. Also, an ion or part of a molecule that specifically binds to form a complex with another molecule.
References in periodicals archive ?
Besides bacterial products many endogenous ligands for various TLRs have been recently described and they may have a potential role in autoimmune synovitis.
The mechanism of action is defined by vertebrate ERs, which bind phytoestrogen ligands, endogenous ligands, and endocrine-disrupting chemicals (EDCs) with specific affinity.
We therefore believe that the odds favor finding a GPCR that binds with Taisho's endogenous ligand with the receptors that we have in-house.
SNAP Bioligand(TM): Synaptic has created a rich endogenous ligand library, currently consisting of approximately three thousand molecules representing diverse structural and biochemical families.
Synaptic will screen these orphan GPCRs in the UFA in order to identify "Hits" from its endogenous ligand library.
In summary, acute administration of cannabinoids and opioids elicits cellular interactions, principally altering the levels of the respective endogenous ligands and subsequent activation or inhibition of the relevant receptors.
polysaccharides) by mimicking endogenous ligands it may be worth to investigate EPs 7630 on the occurrence of carbohydrates.
In these experiments, more than 15 of the predicted novel peptides demonstrated modulation of various GPCRs of clinical interest including some for which there are no known endogenous ligands.
a biopharmaceutical company developing breakthrough medicines to treat autoimmune diseases and cancer, today announced publication of research showing that sterols and sterol sulfates formed during cholesterol biosynthesis and processing are potent endogenous ligands for the retinoic acid receptor-related orphan receptor RORgamma.
To date, little is known about the biochemical processes that mediate the activation of Ahr receptors in the body, or about the endogenous ligands that bind to and activate these receptors.
Eight of these peptides were shown to activate six different GPCRs in a concentration-dependent manner, including some for which there are no known endogenous ligands.

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