endocannabinoid system

(redirected from Endogenous cannabinoid system)

endocannabinoid system

A family of short-lived phospholipid-derived agonists that activate receptors in the brain, liver, muscle, intestine and adipose tissue. The system has roles in regulating energy balance and obesity.
References in periodicals archive ?
D Sulak, in his discussion of the endocannabinoid system on the Norml website, dedicated to reforming marijuana law, noted, "The endogenous cannabinoid system, named after the plant that led to its discovery, is perhaps the most important physiologic system involved in establishing and maintaining human health.
2005) have shown (1) co-localization of CB1 and opioid receptors in various brain regions, (2) alterations of the endogenous opioid system by exposure to cannabinoids and reciprocal alteration of the endogenous cannabinoid system by exposure to opioids, and (3) inhibition of cannabinoid stimulation of dopamine release in the NAcc by opioid antagonists.
Analgesics have long been made from plant sources, cannabis included, and the identification in 1988 of the endogenous cannabinoid system, which functions in parallel to the opioid system, supports this use.