end-stage disease


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end-stage disease

Etymology: AS, ende + OFr, estage + L, dis + Fr, aise, ease
a disease condition that is essentially terminal because of irreversible damage to vital tissues or organs. Kidney or renal end-stage disease is defined as a point at which the kidney is so badly damaged or scarred that dialysis or transplantation is required for patient survival.

end-stage dis·ease

(endstāj di-zēź)
Generalized term for any disorder that is likely to lead to death in a short time.

end-stage disease,

References in periodicals archive ?
Admissions who were unmarried, older, receiving Medicaid per diem, cognitively impaired or Alzheimer's or other dementia diagnosis, ADL dependent, incontinent, and with a psychiatric disorder, diabetes, cancer, or an end-stage disease diagnosis were less likely to be discharged to the community.
6) However, because of the progressive and irreversible nature of large joint involvement, total joint replacement remains the only effective treatment for end-stage disease.
In this classification, stage A includes asymptomatic patients at risk for developing HF with no structural cardiac involvement, stage B includes asymptomatic patients at risk for developing HF with structural cardiac involvement, stage C includes patients with past/current symptoms of HF associated with structural heart disease, and stage D includes symptomatic patients with end-stage disease requiring specialized treatment strategies such as mechanical circulatory support, continuous inotropic infusions, cardiac transplantation, or hospice care.
In patients with end-stage disease, usually the result of diabetes or hypertension, kidney function typically is no more than 10% to 15%, noted Kaplan.
Patients with knee osteoarthritis (OA) secondary to athletic trauma often develop end-stage disease before age 55.
The inadequate supply of suitable donors has rapidly become the major obstacle to further extension of this life-saving therapy to patients being maintained on dialysis or dying with end-stage disease of other vital organs.
DIGNITY Trial to Combine ThermoDox([R]) with Heat to Treat End-Stage Disease
Trials of these agents versus another class of medication did not show differences in progression to end-stage disease or other indicators of function.
The finding might be related to the inability to accurately predict life expectancy in these patients, compared with patients who have terminal cancer or another end-stage disease.
Despite a favorable safety and efficacy profile, the routine use of QUADRAMET for the palliation of disseminated painful bone metastases has commonly been reserved for those patients with end-stage disease when other treatment options have been exhausted," said A.
Asymptomatic patients who are at high risk for developing heart failure are classified as stage A; asymptomatic patients with cardiac structural abnormalities or remodeling are considered stage B; patients with current or prior symptoms are stage C; and patients with refractory end-stage disease are stage D.
Patients with chronic kidney disease that has not yet become end-stage disease should be put on a regimen of good blood pressure control, using an angiotensin-converting enzyme inhibitor as one of the antihypertensive drugs they receive, he said.