83) The chemical literature indicated at least ten separation techniques that could be tried, and Sanofi's actual approach--diasteromeric salt formation--required five months of experimenting with "diverse salt-forming compositions and conditions, in the hope of coming upon a lucky combination of reagents that will preferentially select one of the enantiomers
and crystallize from the solution in optically pure form.
1986) Resolution of enantiomers
by HPLC on optically active poly(triphenylmethyl methacrylate).
The L-Phe and D-Phe imprinted membranes prepared by AA and AN successfully recognize template facilitate permeation of template and reject other enantiomer
It is also interesting to note that there were detectable antipode present in both single enantiomer
standards (S(+) carvone and R(-) carvone).
A combination of methanol/acetonitrile/water in the mobile phase is mandatory for separation of HBCD enantiomers
The S(+) enantiomer
is associated with prostaglandin inhibition and toxicity and the R(-) enantiomer
is linked with analgesic action and protection of gastrointestinal tract.
Pharmacokinetics and pharmacodynamics of the enantiomers
of warfarin in man.
Of all the forms, the studies of its threo diastereomer revealed that d-threo isomer has been found to be more active and also showed significant metabolic difference than l-threo enantiomer
114) An equal mixture of enantiomers
is termed a racemic mixture.
The common analogy used to illustrate the relationship between enantiomers
is the relationship between a left and a right hand.
The system is suited for chiral separations where large volumes of enantiomers
are being purified by stacked injections.
As to novelty, it was common ground, consistent with EPO and English case law (in contrast, for example, to that in Germany as to this issue), that the prior disclosure of a racemate did not in itself amount to a disclosure of each of its enantiomers