MMP20

(redirected from Enamelysin)

MMP20

A gene on chromosome 11q22.3 that encodes matrix metalloproteinase 20, which degrades amelogenin, the major protein of the enamel matrix, and two macromolecules of the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein. MMP20 may play a central role in tooth enamel formation. It is also the retired HUGO symbol for what is now designated MMP25, see there.

Molecular pathology
Defects in MMP20 cause amelogenesis imperfecta type 2A2.
References in periodicals archive ?
2-4) Secreted-type MMPs can be classified into 6 subgroups according to their substrate specificity and structural differences (2): (1) collagenases, including tissue collagenase (MMP1), neutrophil collagenase (MMP8), and collagenase 3 (MMP13); (2) gelatinases, such as gelatinase A (MMP2) and gelatinase B (MMP9); (3) stromelysins, including stromelysin 1 (MMP3) and stromelysin 2 (MMP-10); (4) matrilysins, such as matrilysin 1 (MMP7) and matrilysin 2 (MMP26); (5) furin-activated MMPs, including stromelysin 3 (MMP-13) and epilysin (MMP 28); and (6) other MMPs such as metalloelastase (MMP12), MMP19, enamelysin (MMP-20), MMP21, and MMP-27.
Enamelysin and kallikrein-4 mRNA expression in developing mouse molars.