biological half-life

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biological half-life

n.

biological half-life

the time required for the body to eliminate half of an administered dose of any substance by regular physiological processes. The biological half-life is approximately the same for stable and radioactive isotopes of a specific element. Also called metabolic half-life. See also effective half-life, half-life.
Biology The time required for one half of the total amount of a particular substance in a biological system to be degraded by biological processes when the rate of removal is nearly exponential
Nuclear physics The length of time required for one half of a radioactive substance to be biologically eliminated from the body

biological half-life

T1/2 Biology The time required for 1⁄2 of the total amount of a particular substance in a biologic system to be degraded by biological processes when the rate of removal is nearly exponential Radiation physics The length of time required for1/2 of a radioactive substance to be biologically eliminated from the body
References in periodicals archive ?
Further, prenatal exposure reductions for organic chemicals with human biotransformation half-lives (90 days) approaching the elimination half-life of methylmercury (40-50 days) were predicted to closely mirror those for the 1-year transformation half-life estimates, with maximal declines reaching 96% (see Supplemental Material, Figure S2).
PEG-INTRON (peginterferon alfa-2b), recombinant interferon alfa-2b linked to a 12,000 dalton polyethylene glycol (PEG) molecule, is a once-weekly therapy designed to optimize the balance between antiviral activity and elimination half-life.
We calculated the apparent elimination half-life in each individual for each dioxin congener and examined factors potentially influencing elimination rates and the impact of estimated ongoing background exposures on rate estimates.
3] receptor antagonist (RA) with a strong receptor binding affinity, a long plasma elimination half-life, and a unique mechanism of action compared to older 5-HT[sub.
The elimination half-life of DDS averages between 24 and 30 hours, with significant variability ranging between 14 and 83 hours (4).
The elimination half-life is unknown, but the medium molecular weight (518) suggests that the drug will cross the placenta.
Since warfarin has a relatively high elimination half-life (10-14 h in animals and 40-46 h in humans; Hewick and McEwen, 1973; Laliberte et al.
The drug has a very long elimination half-life from maternal tissues (weeks to months), so stopping the drug when pregnancy is confirmed will not prevent embryo/fetal exposure.
Alprazolam's short elimination half-life is responsible for the inconvenience of four daily doses.
In patients with normal kidney function, the elimination half-life of sulfamethoxazole is 9 h and that of trimethoprime is 10 h.

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