taliglucerase alfa

(redirected from Elelyso)

taliglucerase alfa

(tali-gloo-ser-ase al-fa) ,

Elelyso

(trade name)

Classification

Therapeutic: orphan drugs
Pharmacologic: enzymes
Pregnancy Category: B

Indications

Long-term replacement therapy in adults with confirmed Type 1 Gaucher disease.

Action

Prevents the accumulation of glucocerebrosides in cells. Replaces glucocerebrosidases that are deficient in type 1 Gaucher’s disease.

Therapeutic effects

Improvement in symptoms of Gaucher disease (anemia, thrombocytopenia, bone disease, splenomegaly, and hepatomegaly)

Pharmacokinetics

Absorption: IV administration results in complete bioavailability
Distribution: Unknown.
Metabolism and Excretion: Unknown.
Half-life: 18.9–28.7 min

Time/action profile

ROUTEONSETPEAKDURATION
IVunknownend of infusion2 wk

Contraindications/Precautions

Contraindicated in: None noted.
Use Cautiously in: Obstetric: Use during pregnancy only if clearly needed Lactation: Use cautiously in nursing women Pediatric: Safe and effective use in children has not been established

Adverse Reactions/Side Effects

Miscellaneous

  • allergic reactions including anaphylaxis
  • infusion reactions

Interactions

Drug-Drug interaction

None noted.

Route/Dosage

Intravenous (Adults) 60 Units/kg every other week (range 11–73 Units/kg)

Availability

Lyophilized powder for IV injection (requires reconstitution): 200 Units/vial

Nursing implications

Nursing assessment

  • Monitor for an improvement in symptoms including hepatomegaly, splenomegaly, anemia, thrombocytopenia, bone demineralization, and increased appetite and energy level periodically throughout therapy. Assess liver and spleen size every 6 mo to determine effectiveness of therapy.
  • Assess for signs and symptoms of anaphylaxis (angioedema, dyspnea, wheezing, coughing, cyanosis, hypotension). Stop infusion immediately and treat symptomatically.
  • Monitor for signs and symptoms of infusion reactions (headache, chest pain, asthenia, fatigue, urticaria, erythema, increased BP, back pain, flushing). Treat by slowing infusion or with antihistamines or antipyretics. Pretreatment with antihistamines and/or corticosteroids may be used.

Potential Nursing Diagnoses

Fatigue (Indications)
Deficient knowledge, related to medication regimen (Patient/Family Teaching)

Implementation

  • Patients treated with imiglucerase can be switched to taliglucerase at the same dose.
  • Remove required vials from refrigerator; do not leave at room temperature for longer than 24 hr. Reconstitute each vial with 5.1 mL of Sterile Water for Injection for a volume of 5.3 mL. Mix gently; do not shake. Solution is clear and colorless; do not administer solutions that are discolored or contain particulate matter. Vials are for single use; discard solution.Diluent: Withdraw 5 mL from each vial and dilute with 100–200 mL 0.9% NaCl.Mix gently; do not shake.
  • Rate: Initial infusion rate should be 1.3 mL/min; if tolerated, may increase to 2.3 mL/min. Infuse over 60–120 min; total infusion should be administered over at least 1 hr.

Patient/Family Teaching

  • Inform patient of the purpose of this medication and the importance of treatment every 2wk. taliglucerase helps control the symptoms but does not cure Gaucher’s disease. Lifelong therapy may be required.
  • Instruct patient to notify health care professional if signs and symptoms of anaphylaxis or infusion reactions occur.
  • Advise female patient to notify health care professional if pregnancy is planned or suspected or if breastfeeding.
  • Emphasize the importance of follow-up examinations and lab tests.

Evaluation/Desired Outcomes

  • Increasing hemoglobin and platelet counts and decreasing acid phosphatase levels, hepatomegaly, and splenomegaly. In pediatric patients, cachexia and wasting should diminish.
References in periodicals archive ?
ELELYSO is therefore now indicated for long-term enzyme replacement therapy (ERT) for adult and pediatric patients with a confirmed diagnosis of Type 1 Gaucher disease.
That promises more competition in some established areas, with Pfizer, for example, launching its new Gaucher disease drug Elelyso at a 25% discount to Genzyme's Cerezyme.
PFE) as per which Protalix will continue to manage, administer and sponsor existing, ongoing clinical trials in relation with Elelyso (taliglucerase alfa).
Currently, Protalix is sponsoring adult and pediatric extension studies of Elelyso.
Elelyso (taliglucerase alfa) for Gaucher disease, developed by Protalix in partnership with Pfizer: FDA decision on New Drug Application (NDA) resulted in approval.
under the companies' global commercial agreement for ELELYSO (taliglucerase alfa).
Food and Drug Administration's (FDA) approval of ELELYSO for the treatment of type 1 Gaucher disease on May 1.
At Protalix, our passion to develop ELELYSO was strongly driven by our personal experience with family members and friends who have to live with this disease every day," said David Aviezer, Ph.
Through the GPS program, Pfizer will provide an assistance program covering 100 percent of prescription co-pay expenses for eligible patients on ELELYSO who have commercial health insurance.
3 Protalix's Elelyso (taliglucerase alfa) for Gaucher Disease 8
1 Results of the Pivotal Phase III Trial of Elelyso 10