Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles
Human MGST1 protein can catalyze the conjugation of glutathione to electrophiles
and the reduction of lipid hydroperoxides and is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress (Iida et al.
The elimination of GS-conjugates seems to be especially important in cases where the conjugation leads to bioactivation because of genotoxic electrophiles
reacting with guanidine in DNA (Ishikawa et al.
43 GSTT2B Glutathione Conjugation of S-transferase theta reduced glutathione 2B (gene/pseudogene) to electrophiles
Hepatoprotection by NAC could be due to effective detoxification of electrophiles
generated by arsenic as well as its rapid elimination/excretion from the body.
Writing for professionals, the authors cover theoretical studies on acetylenic scaffolds, synthesis of heterocycles and carbocycles by electrophilic cyclization of alkynes, addition of terminal acetylides to CO and CN electrophiles
, transition metal acetylides, acetylenosaccharides, semiconducting poly(arylene ethylene)s, polyynes via alkylidene carbenes and carbenoids, macrocycles based on phenylacetylene scaffolding, carbon-rich compounds, shape-persistent acetylenic macrocycles for ordered systems, and chiral acetylenic macromolecules.
An additional advantage of this technique is the ability to identify protein targets of reactive electrophiles
and map the adducts to the specific amino acid (29).
The carbon-zinc bond could be functionalized by treatment with electrophiles
such as [D.
This acid-base reaction in turn creates many pendant electrophiles
along the backbone of the EXXPRO rubber.
It has been reported that intake of diets containing powdered preparations of brussels sprouts, cabbage, coffee beans, or tea leaves increased the activity of glutathione-S-transferase (GST), which catalyses the binding of electrophiles
to glutathione (GSH) (Sparnins et al.
A comprehensive and contemporary treatment of the chemistry of hydrocarbons (alkanes, alkenes, alkynes, and aromatics) towards electrophiles
, Hypercarbon Chemistry (Second Edition) deals with all major aspects of such chemistry involved in hydrocarbon transformations, and of the structural and reaction chemistry of carboranes, mixed hydrides in which both carbon and boron atoms participate in the polyhedral molecular frameworks.
2003), and others have proposed a method to measure protein adducts formed by all reactive electrophiles
(Rappaport et al.