Edmonton protocol


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Edmonton protocol

A glucocorticoid-free immunosuppressive regime for pancreatic islet transplantation. It involves five doses of daclizumab over and an eight week period, sirolimus daily for three months and then tacrolimus twice daily.
References in periodicals archive ?
Early hopes for the Edmonton Protocol were quickly tempered, howver.
The collaboration will also seek to position the Cell Pouch through next generation improve ments to the Edmonton Protocol to expand access to cell transplant to a much wider patient population.
A few may be treated with the so-called Edmonton Protocol, in which the missing pancreatic cells are transplanted from cadavers.
Last year, the latest report on the Edmonton protocol found that of 36 patients, 21 initially were able to ditch their insulin needles.
International trial of the Edmonton protocol for islet transplantation.
While we introduced both our allotransplantation and xenotransplantation plans in this meeting, the primary focus was our near-term plan to build upon the promising results of the Edmonton Protocol studies in 2002.
The breakthrough in islet transplantation began in the summer of 2000 with the reported clinical success of what since has come to be known as the Edmonton protocol.
Since 1999, close to 500 patients have received the cadaveric cells through variations of the Edmonton Protocol, a procedure developed in Canada for transplanting cadaveric islet cells into people with type 1 diabetes.
Among the current Edmonton Protocol patients, 85% were completely insulin independent at 1 year, but only 50% remained insulin independent by 5 years.
Shapiro, who is widely acclaimed for his development of the Edmonton Protocol, received the award for "Outstanding Scientific Achievement" from Lacy during a 2-day conference in Philadelphia, PA, December 2-3 entitled Islet Cell Transplant, Prelude to the Future.
Many clinical trials enroll patients based upon inclusion and exclusion criteria set forth in the Edmonton protocol, including individuals with severe hypoglycemia or metabolic instability and those with significant secondary complications secondary to IDDM, including retinopathy and neuropathy.
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