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Nikolai V., Russian physiologist, 1849-1917. See: Eck fistula, reverse Eck fistula.


A gene on chromosome 1q36 that encodes a member of the ephrin-A receptor subfamily of receptor tyrosine kinases, which promiscuously bind membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signalling into neighbouring cells. Once activated by the ligand ephrin-A1 (EFNA1), it regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signalling pathway. It may participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration.

During development, EPHA2 may function in distinctive aspects of pattern formation and development of several foetal tissues, such as angiogenesis, early hindbrain development and epithelial proliferation, and branching morphogenesis during mammary gland development. It is thought to regulate lens fibre cells’ shape and interactions and to be important for lens transparency development and maintenance. With ephrin-A2 (EFNA2), it may play a role in bone remodelling by regulating osteoclastogenesis and osteoblastogenesis.

EPHA2 interacts with ACP1, ANKS1A, ARHGEF16, CLDN4, DOCK4, ELMO2, INPPL1, PIK3R1, PIK3R2, PIK3R3, PTK2/FAK1, PTPN11, SLA, VAV2, and VAV3. 

Molecular pathology
Defects in EPHA2 cause cataract cortical age-related type 2 (age-related cataract cortical type 2) and cataract posterior polar type 1 (posterior polar cataracts type 2).
References in periodicals archive ?
There has been tremendous interest from industry due to the unique material properties and low cost of this alloy," said David Weiss, vice president of engineering/R&D, Eck.
Cheese is believed to be an Eck original," he said, but "Eck uses a variety of cheeses to describe different levels and locations of fastballs--high cheese, hot cheese, educated cheese, sneaky cheese and good cheese.
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In 1973, Eck joined ADS as vice president of sales and marketing.
Eck does both in her book, showing that this verse isn't as clear a statement about the exclusive path of Christianity as some may suggest and that there are other verses which affirm religious diversity.
Paul Eck at Analytical Research Laboratories, Inc, and The Eck Institute of Bio-energetics and Nutrition, has established protocols for an ultimate suggestion of toxic levels of the mineral copper.
When you're doing it every night then you feel like your Johnny Eck, a man born without a body.
And the latest pictures of Big Eck and his knees are not a pretty sight.
What really sets [Colonial Williamsburg] apart is the idea that we want kids to be able to ask a professional historian a question and get an answer, and through that to really generate some excitement for history," says Dale Van Eck, who produces the field trips and handles educational outreach.
THE ECK RECALLS HOW HE learned his days as a starting pitcher were officially history.