Epstein-Barr virus

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Epstein-Barr virus

 [ep´stīn bahr´]
a herpesvirus of the genus Lymphocryptovirus, one of the etiologic agents of infectious mononucleosis. It has been isolated from cells cultured from Burkitt's lymphoma and has been found in certain cases of nasopharyngeal carcinoma. There may be an association between EBV and chronic fatigue syndrome. High titers of EBV are present in some tumors, but a causative role has not been proven. Called also EB virus.

Ep·stein-Barr vi·rus (EBV),

(ep'stīn băr), Avoid the mispronunciation ep'stēn.
a herpesvirus in the genus Lymphocryptovirus that causes infectious mononucleosis and is also found in cell cultures of Burkitt lymphoma; associated with nasopharyngeal carcinoma.

Epstein-Barr virus

(ĕp′stīn-bär′)
n. Abbr. EBV
A herpesvirus that is the causative agent of infectious mononucleosis. It is also associated with various types of human cancers.

Epstein-Barr virus (EBV)

[ep′stīnbär′]
Etymology: Michael A. Epstein, b. 1921, English pathologist; Yvonne M. Barr, twentieth-century English virologist; L, virus, poison
the herpesvirus that causes infectious mononucleosis and is associated with nasopharyngeal sarcoma, Hodgkin's disease, B cell lymphoma, leukoplakia, central nervous system lymphoma in AIDS, and Burkitt's lymphoma, especially in immunodeficient patients such as posttransplantation patients on immunosuppressive therapy. It is also thought to cause oral hairy leukoplakia. One of the most common human viruses, it resides in the salivary glands, is transmitted with saliva, and continues to be shed. EBV is ubiquitous. By 40 years of age 99% of the U.S. population has serological evidence of EBV infection. Infection is often asymptomatic. There is no specific treatment. No antiviral drugs are available.

Epstein-Barr virus

A double-stranded DNA virus which belongs to the 8-member herpesvirus family. Immature EBV particles are 75–80 nm and appear in the cytoplasm and nucleus of infected host cells; mature infectious particles are 150–200 nm and are cytoplasmic. EBV was first found in a Ugandan child with Burkitt’s lymphoma.

Disease associations
Infectious mononucleosis is the most common disease associated with EBV infection. Others include aplastic anaemia, Burkitt’s lymphoma (usually African type), hairy leukoplakia, histiocytic sarcoma in patients with kidney transplants and the immunocompromised. EBV facilitates the development of lymphoproliferative disorders (e.g., Hodgkin and non-Hodgkin lymphomas), angiocentric immunoproliferative lesions, Izumi fever, immunoblastic lymphoma, thymic carcinoma, and undifferentiated nasopharyngeal carcinoma. Serologic markers are used to detect active EBV infection and determine the stage of infection.

Epstein-Barr virus

Human herpesvirus-4 Virology A double-stranded DNA virus that causes infectious mononucleosis, and belongs to the 8-member herpesvirus family; immature EBV particles are 75-80 nm and appear in the cytoplasm and nucleus; mature infectious particles are 150-200 nm and are cytoplasmic; it is associated with aplastic anemia, Burkitt's lymphoma–usually African type, hairy leukoplakia, histiocytic sarcoma in renal transplants and immunocompromise; EBV facilitate lymphoproliferative disorders–eg, Hodgkin's disease–ID'd by PCR, Southern blot, and in situ hybridization, angiocentric immunoproliferative lesions, NHL, Izumi fever, immunoblastic lymphoma, thymic carcinoma, undifferentiated nasopharyngeal carcinoma–mainland China; several serologic markers are used to detect active EBV infection, and determine the stage of infection
Epstein-Barr virus
Early Antigen Ab Present early in infection, usually disappears.
Viral Capsid Ab-IgG ↑ After infection and remains positive; ↑ dramatically with re-infection.
Viral Capsid Ab-IgM ↑ With infection and disappears; ↑ with re-infection.
Nuclear Ab –IgG ↑ With infection and remains positive.
Nuclear Ab –IgM ↑ For 4-6 weeks; post-infection becomes negative; ↑ with re-infection

Ep·stein-Barr vi·rus

(EBV) (ep'stīn bahr vī'rŭs)
A herpesvirus that causes infectious mononucleosis and is also found in cell cultures of Burkitt lymphoma; associated with nasopharyngeal carcinoma.
Synonym(s): human herpesvirus 4.

Epstein-Barr virus

A member of the herpes family of viruses and the cause of GLANDULAR FEVER (infective mononucleosis). It is also associated with cancer of the back of the nose (nasopharyngeal carcinoma) in Chinese people and with BURKITT'S LYMPHOMA. (Michael Anthony Epstein, English pathologist, b. 1921 and Yvonne M. Barr, English virologist, b. 1932).

Epstein-Barr virus (EBV)

A virus in the herpes family that causes mononucleosis.

Epstein,

Michael Anthony, English virologist, 1921–.
Epstein-Barr virus - a herpesvirus that causes infectious mononucleosis. Synonym(s): EB virus

Barr,

Yvonne M., English virologist, 1932–.
Epstein-Barr virus - see under Epstein, Michael Anthony

Epstein-Barr virus

; EBV causative organism of infectious mononucleosis (glandular fever); there is a link between onset of systemic lupus erythematosus (SLE) and seropositivity to EBV

Epstein-Barr virus,

n.pr a herpes virus responsible for mononucleo-sis that is linked to some types of chronic fatigue syndrome and Burkitt's lymphoma.

Ep·stein-Barr vi·rus

(EBV) (ep'stīn bahr vī'rŭs)
A herpesvirus that causes infectious mononucleosis and is also found in cell cultures of Burkitt lymphoma; associated with nasopharyngeal carcinoma.
Synonym(s): human herpesvirus 4.

Epstein-Barr virus (EBV),

n.pr a herpesvirus associated with Burkitt's lymphoma and reported in cases of infectious mononucleosis; more recently reported to be associated with AIDS.

Epstein-Barr virus

see burkitt's lymphoma.