KLF4 A gene on chromosome 9q31 that encodes a protein of the Krüppel-like family of transcription factors that can act as an activator and repressor. KLF4 binds to its own promoter region and activates self-transcription; it regulates expression of key transcription factors during embryonic development and plays an important role in keeping embryonic stem cells in stasis, preventing their differentiation. KLF4 is required for the barrier function of the skin and the ocular surface. It is involved in epithelial cell differentiation and may play a role in skeletal and kidney development. KLF4 contributes to downregulating p53/TP53 transcription.