NTRK3

(redirected from ETV6-NTRK3 fusion)

NTRK3

A gene on chromosome 15q25 that encodes TrkC receptor, a tyrosine-protein kinase receptor activated by neurotrophin-3 (NT-3) and is found on proprioceptive sensory neurons; its substrates include SHC1, PI-3 kinase and PLCG1.
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References in periodicals archive ?
It will stain positive for vimentin, and genetic analysis will show a t(12;15) (p13;q25) translocation with a corresponding ETV6-NTRK3 fusion gene, diagnostic for IF.
Mammary analogue secretory carcinoma of salivary glands, containing the ETV6-NTRK3 fusion gene: a hitherto undescribed salivary gland tumor entity.
A fluorescence in situ hybridization study of ETV6-NTRK3 fusion gene in secretory breast carcinoma.
Secretory breast carcinomas with ETV6-NTRK3 fusion gene belong to the basal-like carcinoma spectrum.
Secretory carcinoma of the breast containing the ETV6-NTRK3 fusion gene in a male: case report and review of the literature.
2) Other renal tumors of childhood have been associated with recurring genetic abnormalities: deletion or mutations of WT1 and p53 in some Wilms tumors, t (12;15) creating the ETV6-NTRK3 fusion gene in congenital mesoblastic nephroma, and INI1 deletions or mutations in malignant rhabdoid tumors.