ELF3

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ELF3

A gene on chromosome 1q32.2 that encodes a transcriptional activator which binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. ELF3 transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters; it acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. It may: play a key role in epithelial cell differentiation and tumourigenesis; act as a critical downstream effector of the ERBB2 signalling pathway; be associated with breast development and involution; and play a key role in regulating transcription with TATA-less promoters in preimplantation embryos, which is essential for their development. ELF3 is expressed exclusively in tissues with a high content of terminally differentiated epithelial cells, including the mammary glands, colon, trachea, kidneys, prostate, uterus, stomach and skin.
References in periodicals archive ?
In July, ESX will produce a webinar on security robotics and distribute a digital special report on security robotics.
About ESX Owned and sponsored by industry leading trade associations, ESA and CSAA, ESX is the only major, national trade event focused exclusively on the needs of security installation, integration and monitoring teams.
The awards, which are presented on the ESX show floor, are judged by a distinguished panel of industry experts, including members of the Electronic Security Association (ESA) and Central Station Alarm Association (CSAA), co-owners of ESX.
2, VMware ESX 3i for HP ProLiant supports management tools from the HP Insight Control portfolio to unify the management of virtual and non-virtual machines.
Greene and other VMware executives highlighted the new VMware ESX 3i agreements with representatives from Dell, HP and IBM during today's VMworld Europe general session keynote presentations.
Supports scheduling; VMware ESX, VMware ESXi and vSphere; and change block tracking (CBT)
a leading developer of storage management software, announced today that its flagship Data Storage Server (DSS(TM)) IP-Storage operating software has now been certified to work with VMware ESX Server 3.
Companies looking to invest in the industry and participate in the ESX show floor or expand their presence are encouraged to act quickly, as space is running out.
Down time, casual connection and plain old fun has always been a part of the ESX concept," says John Knox, president of Knox Integrated Systems, vice president/president-elect of ESA and unofficial social chair of ESX.
VMware ESX abstracts server processor, memory, storage and networking resources into multiple virtual machines.
Kristen Simmons is one of the leading voices in marketing and the customer experience, and during her presentation, she'll show ESX attendees how they can better engage their customers, build a strong following of customer advocates, and, ultimately, create a sustainable business model," says George De Marco, ESX Chair.
With the Early Bird registration deadline being extended, this is another opportunity for companies to secure the discounted pricing and join their colleagues at ESX in Charlotte," says De Marco.