MAP3K8

(redirected from ESTF)
Also found in: Acronyms.

MAP3K8

An oncogene on chromosome 10p11.23 that encodes a MAPK kinase kinase belonging to a protein kinase signal transduction cascade. MAP3K8 is required for TLR4 activation of the MEK/ERK pathway; it activates NF-kappaB 1 by stimulating proteasome-mediated proteolysis of NF-kappaB 1/p105.

Each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of three protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which in turn activates a specific MAPK.
References in periodicals archive ?
The ESTF is an opportunity to introduce government representatives to smaller-sized information security technology vendors whose innovative approaches can help to continually assess and prevent security risks in the nation's critical infrastructure.
We are very pleased to have our products reviewed at the ESTF," said netzentry CEO, Elizabeth Perry.