beta-lactamase

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β-lac·ta·mase

(lak'tă-mās),
An enzyme produced by many species of bacteria that disrupts the four-membered β-lactam ring of penicillin and cephalosporin groups of antibiotics, destroying their antimicrobial activity. The ability of an organism to produce a β-lactamase may be chromosomal and constitutive or a plasmid-associated acquired property.

β-lactamase

/β-lac·ta·mase/ (lak´tah-mās) any of a group of enzymes, produced by almost all gram-negative bacteria, that hydrolyze the β-lactam ring of penicillins and cephalosporins, destroying their antibiotic activity. Individual enzymes may be called penicillinases or cephalosporinases based on their specificities.

beta-lactamase

(bā′tə-lăk′tə-mās′, -māz′, bē′-)
n.
Any of various enzymes that hydrolyze and inactivate beta-lactam antibiotics such as penicillin, found in many antibiotic-resistant bacteria.

beta-lactamase

[-lak′təmāz]
Etymology: lactam, a cyclic amide, ase, enzyme
a bacterial enzyme that catalyzes the hydrolysis of the beta-lactam ring of some penicillins and cephalosporins, producing penicilloic acid and rendering the antibiotic ineffective. Also called cephalosporinase, penicillinase.

be·ta-lac·ta·mase

(bā'tă lak'tā-mās)
An enzyme produced by many species of bacteria that disrupts the four-membered β-lactam ring of penicillin and cephalosporin groups of antibiotics, destroying their antimicrobial activity.
Synonym(s): penicillinase.

β-lactamase

either of two enzymes: β-lactamase I is penicillinase; β-lactamase II is cephalosporinase.
References in periodicals archive ?
In phenotypic chromogenic agar plate method of ESBLs screening, out of the 108 isolates included in our study 79% (85 of 108) were found as ESBL positive.
coli and klebsiellae pneumoniae should be properly detected for ESBL confirmation and reported accordingly.
91 In the present study, ESBL production was found to be 84 out of 228 (36.
coli strain for Ceftazidime <22mm and for Cefotaxime < 21mm is presumptively taken to indicate ESBL production.
Further investigation on our study isolates could include the analysis of ESBL enzyme type, phylogenic group or sequence type, to determine any clonal relationship or association with multidrug resistance in our population.
Comprehensive epidemiologic data and characterization of ESBL-producing isolates among hospitalized and non hospitalized in Iran are still rarely documented and previous studies failed in extend number of patients, long-term study and comprehensive epidemiologic data despite of their useful content leading to a global view on ESBL producing bacteria in Iran.
Primers used in the study for detecting the ESBL genes Primer Sequence Product- Reference size (bp) SHV-F 5' ATT TGT CGC TTC TTT ACT CGC-3' 1,018 bp 14 SHV-R 5' TTT ATG GCG TTA CCT TTG ACC-3' CTXMU-1 5' ATG TGC AGY ACC AGT AAR GT 3' 544 bp 14 CTXMU-2 5' TGG GTR AAR TAR GTS ACC AGA 3' TEM F 5' ATA AAA TTC TTG AAG ACG AAA 3' 1,076 bp 15 TEM R 5' GAC AGT TAC CAA TGC TTA ATC 3'
A further seven children have been correctly identified as being at risk of developing the bug ESBL, which is resistant to common antibiotics.
This observational study was carried out from January 2012 to August 2012 to see the frequency and antibiotic susceptibility of ESBL producers E.