beta-lactamase

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β-lac·ta·mase

(lak'tă-mās),
An enzyme produced by many species of bacteria that disrupts the four-membered β-lactam ring of penicillin and cephalosporin groups of antibiotics, destroying their antimicrobial activity. The ability of an organism to produce a β-lactamase may be chromosomal and constitutive or a plasmid-associated acquired property.

β-lactamase

/β-lac·ta·mase/ (lak´tah-mās) any of a group of enzymes, produced by almost all gram-negative bacteria, that hydrolyze the β-lactam ring of penicillins and cephalosporins, destroying their antibiotic activity. Individual enzymes may be called penicillinases or cephalosporinases based on their specificities.

beta-lactamase

(bā′tə-lăk′tə-mās′, -māz′, bē′-)
n.
Any of various enzymes that hydrolyze and inactivate beta-lactam antibiotics such as penicillin, found in many antibiotic-resistant bacteria.

beta-lactamase

[-lak′təmāz]
Etymology: lactam, a cyclic amide, ase, enzyme
a bacterial enzyme that catalyzes the hydrolysis of the beta-lactam ring of some penicillins and cephalosporins, producing penicilloic acid and rendering the antibiotic ineffective. Also called cephalosporinase, penicillinase.

be·ta-lac·ta·mase

(bā'tă lak'tā-mās)
An enzyme produced by many species of bacteria that disrupts the four-membered β-lactam ring of penicillin and cephalosporin groups of antibiotics, destroying their antimicrobial activity.
Synonym(s): penicillinase.

β-lactamase

either of two enzymes: β-lactamase I is penicillinase; β-lactamase II is cephalosporinase.
References in periodicals archive ?
The phenotypic characteristic of ESBLs is concomitant/ simultaneous resistance to aztreonam, cefotaxime, ceftriaxone, and ceftazidime.
The study showed ESBL producers were highly resistant to cefepime (97.
High prevalence of ESBL emphasizes the need to adopt appropriate control measures to reduce the ESBL burden.
The genotypes of ESBL producing strains largely remain unknown in India; hence the present study was aimed to determine the occurrence of ESBLs in Escherichia coli and Klebsiella pneumoniae, their molecular types and associated risk factors in a tertiary care hospital.
The agency has commissioned a report into ESBL infection and microbiologist Dr Andrew Pearson will lead the investigation.
ESBL screening and confirmation by phenotypic methods: The isolates showing reduced susceptibility to ceftazidime or cefotaxime or both were tested for ESBL production by double disk-diffusion test (DDDT) using four disks (p.
The ESBL bacteria produce enzymes which can break down common antibiotics.
Yesterday health bosses warned of a crisis after it was revealed that the new ESBL superbug has claimed its first victim north of the Border - at Hairmyres Hospital, East Kilbride, Lanarkshire.
But the Executive received the support of Dr Baird, who also sought to play down fears that ESBL was a new superbug.
Coexistence of ESBL and plasmid-mediated quinolone resistance genes in Salmonella and in other Enterobacteriaceae genera have been reported and there are existing reports on extended-spectrum cephalosporin-resistant and ESBL-producing Salmonella isolates (3,4,10).
The unit at Singleton Hospital, in Swansea, was closed to premature babies following the death of a baby from the antibiotic-resistant ESBL strain of E.