ES cells


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ES cells

abbrev. embryonic stem cells. see STEM CELLS.
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Research on cloned ES cells became less active following the generation of induced pluripotent stem cells, or iPS cells, around 2006.
His new direction eventually took him back to Japan where, armed with the expertise gained at Gladstone, he undertook what seemed to be an impossible undertaking: to find out which genetic factors from among hundreds of possibilities instruct ES cells to become other types of cells.
Since the isolation of human ES cells, 2 less controversial stem cell types have been discovered: adult stem (AS) cells and induced pluripotent stem (iPS) cells.
Attempts had been made to isolate ES cells from inbred Kunming mice but few successes were achieved, and especially there are no reports regarding establishment of pES cell lines from them.
The center in Tokyo, the second facility in Japan to produce such cells after Kyoto University, said it will set up a distribution system so that other research institutes would be able to utilize the embryonic stem cells, or ES cells.
Evidence for an in vitro differentiation of ES cells into the neuronal lineage has been reported (10,11).
However, further studies such as defining drug action or the genetic basis of disease using rats have been hindered by the lack of sophisticated, precision genetic engineering, such as that achievable via ES cells in mice.
High-quality mouse ES cells are expected to be important and valuable for drug target validation and drug screening efforts.
With these patient-specific ES cells, we could find new treatments, new drugs and a whole lot more about serious diseases.
The cells are expected to serve as an improved model for human ES cells in studies of regeneration, disease pathology and basic stem cell biology.
However, accepting that we can now manipulate ES cell lines to differentiate into practically any tissue of choice, there remain substantial obstacles before the therapeutic potential of ES cells can be exploited.
In a research setting, Lanza showed that the single blastomere, when fused with existing embryonic stem cells, can essentially "reformat" itself and go on to produce ES cells.