ERN1

ERN1

A gene on chromosome 17q24.2 that encodes the ubiquitously expressed endoplasmic reticulum (ER)-to-nucleus signalling 1 protein, which has intrinsic kinase and endoribonuclease activities and plays a key role in altering gene expression in response to endoplasmic reticulum-based stress signals. ERN1 senses unfolded proteins in the ER lumen, leading to enzyme auto-activation; the active endoribonuclease domain splices XBP1 mRNA, generating a new C-terminus and converting it into a potent unfolded-protein response transcriptional activator, triggering growth arrest and apoptosis.
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Objective 1: Construction of plant transformation binary vectors carrying the legume (Medicago truncatula) symbiosis-specific receptor kinases LYK3, NFP and SYMRK, and the transcription factors NSP1, NSP2, ERN1 and NIN driven by rice/constitutive promoters.
Objective 2: Development of the transgenic rice carrying the receptor protein LYK3, NFP and SYMRK, and the transcription factor NSP1, NSP2, ERN1 and NIN genes.