MAPK7

(redirected from ERK5)
Also found in: Acronyms.

MAPK7

A gene on chromosome 17p11.2 that encodes a member of the MAP kinase family, which integrate multiple biochemical signals and are involved in cell proliferation, differentiation, transcription, regulation and development. MAPK7 is activated by MAPK kinase 5—which is formed from MAPK2K5 and MEK5; it translocates to the nucleus, undergoes phosphorylation and regulates gene expression.
Mentioned in ?
References in periodicals archive ?
In multiple myeloma, the addition of ERK5 inhibition and the established roles of the JAK-STAT and CDK9 pathways in myeloma cell survival and drug resistance suggest that TG02 could be an exciting addition to the armamentarium for this disease.
We are particularly enthusiastic about TG02's modulation of the ERK5 pathway in solid tumors," added Francis Burrows, Ph.
TG02 is a novel orally available, small molecule that targets - equipotently - the major signaling pathways involving ERK5, JAK2, Flt3 and key cell cycle and transcriptional cyclin-dependent kinases (CDKs), with excellent pharmacological and pharmaceutical properties.
They include extracellular signal-regulated kinase (ERK)-I and -2, p38 kinases, ERK5 (big MAPK1) and c-Jun N-terminal kinases (JNKs) (Liu et al.
Besides ERKI/2, also ERK5 was activated by vitamin C during proliferation (Fig.