MAPK7

(redirected from ERK5)
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MAPK7

A gene on chromosome 17p11.2 that encodes a member of the MAP kinase family, which integrate multiple biochemical signals and are involved in cell proliferation, differentiation, transcription, regulation and development. MAPK7 is activated by MAPK kinase 5—which is formed from MAPK2K5 and MEK5; it translocates to the nucleus, undergoes phosphorylation and regulates gene expression.
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The mRNA levels of ERK5 and MAP3K7 were increased in BC tissues compared with noncancerous tissues or NC breast tissues (P<0.
Effect of ectopic miR-143 level on the expression and phosphorylation of ERK5 and MAP3K7 in MCF-7 cells
01), and the mRNA levels of ERK5 and MAP3K7 in cells with miR-143 mimic were remarkably decreased compared with cells with mimic control (P<0.
Effect of ectopic miR-143, ERK5 and MAP3K7 levels on cell growth in MCF-7 cells
In the present study, the level of miR-143 was reduced, while the expression and phosphorylation of ERK5 and MAP3K7 were increased in BC tissues compared with noncancerous tissues or NC breast tissues.
ERK5 is a member of the MAPK family, which has been reported as an enhancer of cell proliferation and progression by mediating the cell cycle, as well as a tumorigenesis (26).
Moreover, we also revealed that miR-143 regulated cyclin D1 expression through down-regulation of ERK5.
In conclusion, the present study reveals that both ERK5 and MAP3K7 may be the target genes of miR-143.
Regulation of cellular functions by the ERK5 signalling pathway.
miR-143 Interferes with ERK5 signaling, and abrogates prostate cancer progression in mice.
ERK5 knockdown generates mouse leukemia cells with low MHC class I levels that activate NK cells and block tumorigenesis.
miR-143 suppresses epithelial-mesenchymal transition and inhibits tumor growth of breast cancer through down-regulation of ERK5.