MAPK12

(redirected from ERK3)

MAPK12

A gene on chromosome 22q13.33 that encodes a member of the MAP kinase family, which integrate multiple biochemical signals and are involved in cell proliferation, differentiation, transcription, regulation and development. MAPK12 is activated by environmental stress and pro-inflammatory cytokines, in turn phosphorylating downstream
targets. It plays a role in myoblast differentiation and downregulates cyclin D1 in response to hypoxia.
References in periodicals archive ?
Six distinct groups of MAPKs are known that include extracellular signal-regulated kinases (ERK1 and ERK2), c-Jun N-terminal kinases (JNKs), p38 isoforms, ERK5, ERK3/4, ERK3 and ERK 7/8 (Albrecht et al.
ERK3 gene and protein levels were increased at most arsenic doses and time points tested (Figure 4A), whereas RSK1, PKAC[alpha], and PKB[alpha]/aktl all showed consistent decreases in expression following arsenic exposure in both assays (Figure 4B-D).
Comparison between the microarray and kinase assay results shown in Figure 4 indicates a correlation between protein and gene-level changes in response to arsenic exposure for all genes that were examined in both studies: ERK3, ribosomal S6 kinase 1 (RSK1), cAMP-dependent protein kinase alpha-catalytic subunit (PKAC[alpha]), and protein kinase B (PKB/aktl).