MAPK1

(redirected from ERK2)
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MAPK1

A gene on chromosome 22q11.2|22q11.21 that encodes a protein of the MAP kinase family. MAP kinases (e.g., extracellular signal-regulated kinases) integrate multiple biochemical signals, and are involved in cell proliferation, differentiation, transcription, regulation and development. Once MAPK1 is activated by phosphorylation by an upstream kinase, it translocates to the nucleus of the stimulated cell, where it phosphorylates target molecules.
References in periodicals archive ?
4A and B showed that nobiletin suppresses HGF-induced ERK2 and Akt activation but not JNK 1/2 and p38 activation
Rather, Kornblau's team suggests that new drugs being developed to inactive these pathways -- the PKC-alpha, ERK2 and AKT signal transduction pathways -- will be most beneficial when used in combinations individualized for each AML patient.
At the same time, both the protein and phosphorylation levels of MEK1 /2 substrates ERK1 /2 were down-regulated in a differential manner, with the effect being more pronounced for ERK1 (p44) showing a differential influence of 7-epi-nemorosone on the functionality of ERK1 and ERK2, a hypothesis which is worth being studied in further experiments.
Membranes were probed overnight at 4[degrees]C with antibodies against c-Fos (H-125), [beta]-actin (C-2), phosphorylated extracellular signal-regulated kinase 1/2 (p-ERK1/2; E-4), Egr-1 (588), CTGF (L-20), ERK2 (C-14), ER[alpha] (F-10), or GPR30 (N-15), all from Santa Cruz Biotechnology, DBA (Milan, Italy), or ER[beta] from Serotec (Space Import Export, Milan, Italy).
Subcellular localization determines the protective effects of activated ERK2 against distinct apoptogenic stimuli in myeloid leukemia cells.
The phosphorylation of ERK1 and ERK2 was up-regulated in response to BPA25, but not BPA2500, treatment.
1992): activated MEK then phosphorylates ERK1 and ERK2 on tyrosine and threonine residues (Anderson et al.
In the current study, a rat pituitary cancer cell line was used to study the effect of alkylphenols and BPA on ERK1 and ERK2 activation (measured as phosphorylation), both alone and in combination with each physiologic estrogen.
In addition, extracellular signal-regulated kinases ERK1 and ERK2 were completely inactivated, whereas p38 was found activated in human leukemia U937 cells treated with arsenic trioxide ([As.
Leptin stimulates glucose uptake in C2C12 muscle cells by activation of ERK2.