ERBB4


Also found in: Wikipedia.

ERBB4

A gene on chromosome 2q33.3-q34 that encodes a single-pass type-1 membrane protein member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. ERBB4 binds to and is activated by neuregulins and other factors, and it induces various cellular responses, including mitogenesis and differentiation.

Molecular pathology
ERBB4 mutations have been associated with cancer.
Mentioned in ?
References in periodicals archive ?
GILOTRIF is an oral, once-daily kinase inhibitor that is designed to irreversibly bind and inhibit the following receptors: EGFR (ErbB1), HER2 (ErbB2) and ErbB4.
EGFR belongs to a family of receptors, known as HER, composed of four related proteins: EGFR, ERBB2, ERBB3 and ERBB4.
This colorectal cancer study evaluated protein and DNA alterations in the EGFR pathway, including analysis of KRAS, NRAS, HRAS, BRAF, PIK3CA, ERBB4 and HER2 mutations/amplifications, as well as PTEN loss of expression and mutation in KRAS wild-type colorectal cancer patients.
ERBB3 overexpression has recently been finked with resistance to the ERBB protein family member ERBB1 inhibitors in lung cancer (31), and mutation of ERBB4, a closely related receptor tyrosine kinase, inhibits the formation of drug-resistant colonies in PCa cell lines (32), making miR-152 interesting not only as a prognostic marker but also as a therapeutic tool.
This gene, NRG1, codes for the ErbB4 receptor, a protein implicated in synaptic development and function.
32) High-throughput capillary sequencing of 623 genes in 188 lung adenocarcinomas has identified several key pathways involved in lung cancer, as well as some potentially actionable driver mutations in ERBB3, ERBB4, FGFR1, FGFR2, FGFR4, and KDR.
Essential role for Rac in heregulin [31 mitogenic signaling: a mechanism that involves epidermal growth factor receptor and is independent of ErbB4.
Scientists made the mouse by deleting a candidate gene for schizophrenia, ErbB4, from interneurons, which are brain cells that help shower larger decision-making neurons, called pyramidal cells, with inhibition.
One key component of the pathway is a protein called erbB4 that straddles the outer membrane of the neural stem cell.
EGFR (also called erbB1) is the first member of a closely related group of tyrosine kinase receptors known as the erbB family, the remaining three being erbB2, erbB3 and erbB4.
Afatinib is an investigational oral, once-daily irreversible ErbB Family Blocker that specifically inhibits epidermal growth factor receptor (EGFR or ErbB1), human epidermal receptor 2 (HER2 or ErbB2) and ErbB4.
Divergent biological functions of splice variants have previously been reported for 2 isoforms encoded by ERBB4 [v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)] that exhibit markedly opposing effects on mammary epithelium growth and differentiation (27).