ERBB4


Also found in: Wikipedia.

ERBB4

A gene on chromosome 2q33.3-q34 that encodes a single-pass type-1 membrane protein member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. ERBB4 binds to and is activated by neuregulins and other factors, and it induces various cellular responses, including mitogenesis and differentiation.

Molecular pathology
ERBB4 mutations have been associated with cancer.
Mentioned in ?
References in periodicals archive ?
Joshua LaBaer, the new research demonstrated that ibrutinib can also target a little-studied member of the RTK family, known as ERBB4, potentially thwarting the sequence of events leading to progression and growth of other solid tumors.
ARSA (rs6151412, synonymous) and ERBB4 (rs6725041, intronic) are particularly compelling in this setting due to their functional role in [Ca.
For example, using Sanger sequencing, Vlenterie et al (3) were able to identify 8 novel somatic mutations in the following genes: KRAS, CCND1, SEPT09, RNF213, KDR (VEGFR2), CSMD3, MLH1, and ERBB4 (HER4).
EGFR belongs to the erbB family of receptor tyrosine kinases, which also includes [15, 28, 29] ErbB1 (EGFR, HER1), ErbB2 (HER2/neu), ErbB3 (HER 3) and ErbB4 (HER 4).
ErbB4 levels are reduced in the left ventricular tissue of PPCM patients.
73) On the other hand, the NRG1 receptor, ErbB4, is expressed in migrating interneurons.
Overall it is apparent that NRG-1 may play a powerful role in augmenting antioxidant status in neurons expressing its ErbB4 receptor.
The family consists of 4 members, also known as the epidermal growth factor receptors (EGFR): ErbB1 (HER1), ErbB2 (HER2 or Neu), ErbB3 (HER3), and ErbB4 (HER4) [1].
EGFR belongs to a family of receptors, known as HER, composed of four related proteins: EGFR, ERBB2, ERBB3 and ERBB4.
This gene, NRG1, codes for the ErbB4 receptor, a protein implicated in synaptic development and function.
25) In fact, it is known that ErbB4 has direct contact with both NR2A and NR2B, and its location appears to be exclusive to synaptic connections where these molecules exist (Fig.
Neratinib is an investigational oral, multi-targeted inhibitor of the ErbB1 (EGFR), ErbB2 (HER2) and ErbB4 (HER4) kinases, added the companies.