ERBB3


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ERBB3

A gene on chromosome 12q13 that encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases which binds and is activated by neuregulins and NTAK.

Molecular pathology
ERBB3 amplification and overexpression has been described in multiple cancers, including prostate, bladder and breast.
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Upon further analysis of these fetal muscle cells two new cell surface markers called ERBB3 and NGFR were discovered; this enabled the researchers to precisely isolate muscle cells from human tissue and separate them from various cell types created using human pluripotent stem cells.
Coordinate suppression of ERBB2 and ERBB3 by enforced expression of microRNA miR-125a or miR-125b.
39) ITGB4 PTC_6 NO ERBB3 PTC_7 NO EHBP1L1 PTC_8 YES (44, 0.
2007) MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling.
EGFR belongs to a family of receptors, known as HER, composed of four related proteins: EGFR, ERBB2, ERBB3 and ERBB4.
They discovered that four genes (named TENC1, ERBB3, ACVR1B, and DGKA) influence LDL levels.
The researchers discovered that ERBB2's activity sprang from an oversupply of the protein's parent gene, HER2/neu, or by a related protein, ERBB3, when prompted by high levels of the protein heregulin.
For example, Genetics Home Reference notes an "amplification" of the possible-classified ERBB3 gene "and/or overexpression of [its] protein" in bladder tumors in the ERBB3 gene record [31].
Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: Evidence for overexpression in a subset of human mammary tumors.
AV-203 is a monoclonal antibody that selectively targets the receptor ERBB3, a new and promising strategy for treating cancer.
It shares homology with other family members including ERBB2 (HER2/neu), ERBB3, and ERBB4.